Who is sponsoring NCT01938183?

NCT01938183 is sponsored by University of Campinas, Brazil.

What condition does NCT01938183 study?

NCT01938183 studies Chronic Periodontitis.

What drugs are being tested in NCT01938183?

Interventions: Full-mouth periodontal debridement, Metronidazole tablet, placebo gel, Metronidazole benzoate gel.

What is the status of NCT01938183?

NCT01938183 is currently COMPLETED.

Last reviewed 2013-09-04 · How we verify

Full-mouth Periodontal Debridement With or Without Adjunctive Metronidazole Gel in Smoking Patients With Chronic Periodontitis

NCT01938183 Phase 2 COMPLETED

Hypothesis: metronidazole gel applied topically after periodontal debridement in smokers volunteers could improve clinical parameters when compared to metronidazole tablets + periodontal debridement. Method: 30 smokers with chronic periodontitis were randomly assigned into 3 groups: periodontal debridement combined with 3 g placebo gel; periodontal debridement combined with daily topical application of 3 g metronidazole benzoate gel (15%); and periodontal debridement combined with a daily single dose of 750 mg metronidazole. Clinical parameters evaluated were visible plaque, gingival bleeding, probing pocket depth and relative attachment level.

Details

Lead sponsor	University of Campinas, Brazil
Phase	Phase 2
Status	COMPLETED
Enrolment	30
Start date	2006-11
Completion	2011-12

Conditions

Chronic Periodontitis

Interventions

Full-mouth periodontal debridement
Metronidazole tablet
placebo gel
Metronidazole benzoate gel

Primary outcomes

Changes in PPD — Change from baseline to 6 months
Probing pocket depth (PPD) measured from the bottom of the periodontal pocket to the gingival margin were considering four tooth surfaces: mesial, distal, buccal and lingual. Measurements were performed by a calibrated clinician.

Countries

Brazil