Efavirenz and Ritonavir Influence on Human Brain Levo-acetylmethadol (LAAM) Disposition Assessed Using PET Imaging

NCT01935830 EARLY_PHASE1 COMPLETED

The purpose of this study is to determine the effects of the antiretroviral drugs efavirenz and ritonavir on human brain LAAM disposition in vivo.

Details

Lead sponsor	Washington University School of Medicine
Phase	EARLY_PHASE1
Status	COMPLETED
Enrolment	10
Start date	2013-08
Completion	2015-09

Conditions

• Healthy Volunteers

Interventions

• [11c] LAAM
• Ritonavir
• Efavirenz

Primary outcomes

• cerebral [11C]LAAM distribution volume — approximately 3 months
  Blood tests, MRI and PET data analysis and interpretation

Countries

United States