NCT01924208 (Tons2) is a Phase 3 clinical trial of Timothy, Phleum pretense in Healthy, sponsored by Turku University Hospital.

Who is sponsoring NCT01924208?

NCT01924208 is sponsored by Turku University Hospital.

What drugs are being tested in NCT01924208?

Interventions in NCT01924208: Timothy, Phleum pretense, Live attenuated influenza virus, Timothy + attenuated influenza virus.

Is NCT01924208 still recruiting?

NCT01924208 is currently status unknown. Last updated 20 April 2016.

Last reviewed 2016-04-20 · How we verify

NCT01924208: Tons2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

T Cell and Interferon Expression in Tonsils After Sublingual Immunotherapy and/or Nasal Live Attenuated Influenza Vaccine

Status unknown Phase 3 Last updated 20 April 2016

What this trial tests

Phase 3 trial testing Timothy, Phleum pretense in Healthy in 180 participants. Status unknown.

Timeline

1 October 2013

Primary endpoint
1 September 2016

1 September 2016

Quick facts

Lead sponsor	Turku University Hospital
Phase	Phase 3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	basic science
Enrollment	180
Start date	1 October 2013
Primary completion	1 September 2016
Estimated completion	1 September 2016
Sites	4 locations across Finland

Drugs / interventions tested

Timothy, Phleum pretense — full drug profile →
Live attenuated influenza virus — full drug profile →
Timothy + attenuated influenza virus

Conditions studied

Healthy — all drugs for Healthy →

Sponsor

Turku University Hospital

Who can join

Adults 4 to 30, any sex, with Healthy. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Expressions of interferon and T cell and closely related cytokines and transcription factors in tonsils.
Time frame: Up to 3 years
Expressions of IFN-α, IFN-β, IFN-γ, IL-10, IL-13, IL-17, IL-28, IL-29, IL-37, TGF-β, FOXP3, GATA3, RORC2 and Tbet will be analyzed by quantitative real-time PCR.

Sponsor's own description

Hypotheses 1. Immunotherapy induces tolerogenic effects to allergens in T cell regulation in tonsils. 2. Influenza vaccination induces a strong interferon response and decreases Th2 response in tonsils. 3. Influenza vaccination as an adjuvant on immunotherapy induces a better response to immunotherapy.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

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Other Turku University Hospital trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01924208 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Turku University Hospital
Last refreshed: 20 April 2016

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01924208.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing