NCT01896661 is a Phase 3 clinical trial of Diuretics in Hypertension, sponsored by Hospital de Clinicas de Porto Alegre.

Who is sponsoring NCT01896661?

NCT01896661 is sponsored by Hospital de Clinicas de Porto Alegre.

What drugs are being tested in NCT01896661?

Interventions in NCT01896661: Diuretics, Calcium Channel Blockers.

What condition does NCT01896661 study?

NCT01896661 studies Hypertension, Obstructive Sleep Apnea.

Is NCT01896661 still recruiting?

NCT01896661 is currently completed. Last updated 13 July 2016.

Last reviewed 2016-07-13 · How we verify

NCT01896661

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of Antihypertensive Agents Over Sleep Apnea: a Randomized Controlled Trial

Completed Phase 3 Last updated 13 July 2016

What this trial tests

Phase 3 trial testing Diuretics in Hypertension in 53 participants. Completed in 1 February 2016.

Timeline

1 December 2014

Primary endpoint
1 December 2015

1 February 2016

Quick facts

Lead sponsor	Hospital de Clinicas de Porto Alegre
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	53
Start date	1 December 2014
Primary completion	1 December 2015
Estimated completion	1 February 2016
Sites	1 location across Brazil

Drugs / interventions tested

Diuretics — full drug profile →
Calcium Channel Blockers — full drug profile →

Conditions studied

Hypertension — all drugs for Hypertension →
Obstructive Sleep Apnea — all drugs for Obstructive Sleep Apnea →

Sponsor

Hospital de Clinicas de Porto Alegre

Who can join

40 and older, any sex, with Hypertension or Obstructive Sleep Apnea. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Apnea-Hypopnea Index
Time frame: 8 weeks
Number of apneas/hour
Blood Pressure
Time frame: 8 weeks

Sponsor's own description

Obstructive sleep apnea and hypertension are well-known cardiovascular risk factors. Their control could reduce the burden of heart disease across populations. There are several drugs to control hypertension, but the only consistently beneficial treatment to reduce apneas is continuous positive airway pressure. The demonstration that one drug could improve sleep apnea and hypertension would support a novel approach in the treatment of both diseases. The role of fluid retention in sleep apnea is known for several decades. The role of diuretics is well established in hypertension but was never appropriately tested in sleep apnea. Besides to test the efficacy of these drugs, this study will help to understand the mechanisms that link hypertension and sleep apnea and its treatment.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

The effect of antihypertensive agents on sleep apnea: protocol for a randomized controlled trial.
Cichelero FT, Martinez D, Fuchs SC, Gus M, et al · · 2014 · cited 33× · PMID 24382030 · DOI 10.1186/1745-6215-15-1
Effect of antihypertensive agents on sleep apnea and ambulatory blood pressure in patients with hypertension: A randomized controlled trial.
Cichelero FT, Fuchs SC, Jorge JA, Martinez D, et al · · 2024 · cited 1× · PMID 38781664 · DOI 10.1016/j.sleep.2024.05.035
Effects of chlorthalidone plus amiloride compared with amlodipine on short-term blood pressure variability in individuals with hypertension and obstructive sleep apnea: a randomized controlled trial.
Lucca MB, Jorge JA, Cichelero FT, Martinez D, et al · · 2023 · PMID 37466401 · DOI 10.1097/mbp.0000000000000663

Verify or expand the search:

Other trials of Diuretics

Trials testing the same drug.

NCT05527054 — Risk Factors and Machine Learning Model for Diuretics Related Acute Kidney Injury · unknown
NCT05430243 — Empagliflozin as a Novel Therapy in Refractory Ascites · Phase 2, PHASE3 · completed
NCT03645642 — To Study the Safety and Efficacy of Midodrine With Albumin Versus Albumin Alone in Hepatic Hydrothorax · NA · completed
NCT03395951 — Mean Systemic Filling Pressure Continuous Diuretics Critical Care Patients · completed

Other recruiting trials for Hypertension

Currently open trials in the same condition.

NCT07413159 — The "Check, Monitor, Control Hypertension" Study is a 24-month Randomized Trial in Houston Targeting African Americans A · NA · recruiting
NCT07361276 — Observational Study That Will Evaluate Treatment Patterns in the Management of Hypertension in the Public Primary Care S · recruiting
NCT07238556 — A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors · NA · recruiting
NCT07238400 — Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia · Phase 2 · recruiting
NCT07135505 — Early Time-Restricted Eating in Older Adults With Hypertension · NA · recruiting

Other Hospital de Clinicas de Porto Alegre trials

Trials by the same sponsor.

NCT07469722 — POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure · Phase 2, PHASE3 · not yet recruiting
NCT07264179 — Tracheal Cuff Pressure and Postoperative Complications: A Prospective Observational Study. · not yet recruiting
NCT07052058 — Triple-Blind Randomized Clinical Trial of Tocilizumab vs Placebo: Potential Use of an IL-6 Antagonist as an Adjuvant to · Phase 2 · not yet recruiting
NCT06953128 — General Versus Regional Anesthesia in Peripheral Arterial Surgery · NA · not yet recruiting
NCT06934707 — Meal Frequency and Glycemic Control in Individuals With Type 1 Diabetes · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01896661 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital de Clinicas de Porto Alegre
Last refreshed: 13 July 2016

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01896661.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing