NCT01895764 (COMARIS) is a Phase 4 clinical trial of Adalimumab in Ankylosing Spondylitis, sponsored by University Hospital, Tours.

Who is sponsoring NCT01895764?

NCT01895764 is sponsored by University Hospital, Tours.

What drugs are being tested in NCT01895764?

Interventions in NCT01895764: Adalimumab, Methotrexate.

What condition does NCT01895764 study?

NCT01895764 studies Ankylosing Spondylitis.

Is NCT01895764 still recruiting?

NCT01895764 is currently completed. Last updated 3 April 2026.

Last reviewed 2026-04-03 · How we verify

NCT01895764: COMARIS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS)

Completed Phase 4 Last updated 3 April 2026

What this trial tests

Phase 4 trial testing Adalimumab in Ankylosing Spondylitis in 110 participants. Completed in 27 April 2015.

Timeline

20 March 2013

Primary endpoint
27 April 2015

27 April 2015

Quick facts

Lead sponsor	University Hospital, Tours
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	110
Start date	20 March 2013
Primary completion	27 April 2015
Estimated completion	27 April 2015
Sites	11 locations across France

Drugs / interventions tested

Adalimumab (ADALIMUMAB) — full drug profile →
Methotrexate — full drug profile →

Conditions studied

Ankylosing Spondylitis — all drugs for Ankylosing Spondylitis →

Sponsor

University Hospital, Tours

Who can join

18 and older, any sex, with Ankylosing Spondylitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine if association of methotrexate with adalimumab leads to decrease immunogenicity beside adalimumab alone in Ankylosing Spondylitis.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Methotrexate effect on immunogenicity and long-term maintenance of adalimumab in axial spondyloarthritis: a multicentric randomised trial.
Ducourau E, Rispens T, Samain M, Dernis E, et al · · 2020 · cited 39× · PMID 31958280 · DOI 10.1136/rmdopen-2019-001047
The Risk of Adverse Effects of TNF-α Inhibitors in Patients With Rheumatoid Arthritis: A Network Meta-Analysis.
He B, Li Y, Luo WW, Cheng X, et al · · 2022 · cited 21× · PMID 35250992 · DOI 10.3389/fimmu.2022.814429

Verify or expand the search:

Other trials of Adalimumab

Trials testing the same drug.

NCT07398651 — Apremilast and Adalimumab in Psoriatic Arthritis Patients · NA · not yet recruiting
NCT06016517 — Application of the Personalized N-of-1 Trial Design in Patients With Rheumatoid Arthritis · not yet recruiting
NCT07268534 — Biologics in Folliculitis Decalvans : an Adaptative Trial Research · Phase 2 · not yet recruiting
NCT07061574 — A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New On · Phase 1, PHASE2 · recruiting
NCT07352566 — Utilization of a Microdevice for Psoriasis and Atopic Dermatitis · Phase 4 · not yet recruiting

Other recruiting trials for Ankylosing Spondylitis

Currently open trials in the same condition.

NCT07510789 — Impact of Low Back Pain Phenotypes on Function and Quality of Life in Ankylosing Spondylitis · recruiting
NCT07261644 — A Study to Evaluate the Efficacy and Safety of 608 in Adult Subjects With Active Ankylosing Spondylitis(AS) · Phase 3 · recruiting
NCT07390929 — Clinical Trial Study on the Improved New Method of Acupotomy for AS · NA · recruiting
NCT06905288 — Real-world Study on Secukinumab Effectiveness in Biologic-naïve Ankylosing Spondylitis (AS) Patients in Korea. · recruiting
NCT07166874 — The Impacts of Gluten-free Diet in Patients With Ankylosing Spondylitis · NA · recruiting

Other University Hospital, Tours trials

Trials by the same sponsor.

NCT07452978 — Propranolol for Early Secondary Prevention of Post-Traumatic Stress Disorder in Women Victims of Sexual Violence · Phase 2 · not yet recruiting
NCT07443800 — Comorbidity Between Attention Deficit Hyperactivity Disorder and Fibromyalgia · NA · not yet recruiting
NCT07251530 — Communication Enhancement Among Ventilated Patients in Intensive Care · not yet recruiting
NCT07189338 — Apneic Oxygenation With High-flow Nasal Oxygenation After Preoxygenation With Noninvasive Ventilation Before Intubation · NA · not yet recruiting
NCT07054112 — Efficacy of Live Online Course Mindfulness Program on Perceived Fatigue in Hemodialysis Patients · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01895764 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Tours
Last refreshed: 3 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01895764.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing