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Window of Opportunity Study Targeting the Inflammatory Milieu
The purpose of this study is to evaluate the effect of two anti-inflammatory drugs, fish oil capsules and the COX-2 inhibitor celecoxib, on pregnancy associated breast cancer (PABC). Short-term intervention with anti-inflammatory medications will demonstrate a reduction in the inflammation and immune suppressive phenotype of PABC, and decreased metastatic potential in PABC. This unique window in breast cancer management serves as a valuable opportunity to obtain preliminary data on biomarkers and the alterations that occur when the system is troubled by a drug or other intervention which will be instrumental in designing future therapeutic or preventative strategies for larger clinical study.
Details
| Lead sponsor | University of Colorado, Denver |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | COMPLETED |
| Enrolment | 42 |
| Start date | Tue Dec 08 2009 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Mon Dec 14 2015 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Stage IA Breast Cancer
- Stage IB Breast Cancer
- Stage II Breast Cancer
- Stage IIIA Breast Cancer
- Stage IIIB Breast Cancer
- Stage IIIC Breast Cancer
- Stage IV Breast Cancer
Interventions
- Omega-3 fatty acid
- Celecoxib
Countries
United States