A Double Blind Randomised Control Trial to Measure the Effect of the Addition of Clindamycin to Flucloxacillin for the Treatment of Limb Cellulitis (C4C)

NCT01876628 Phase 4 COMPLETED

The aim of this study is to see whether the addition of Clindamycin, a protein inhibiting antibiotic, to the standard antibiotic treatment of limb cellulitis, with Flucloxacillin, results in less tissue damage and a more rapid resolution of both systemic and local features, in a cost-effective manner. This study is a randomised controlled trial comparing Clindamycin with placebo.

Details

Lead sponsor	University Hospitals Bristol and Weston NHS Foundation Trust
Phase	Phase 4
Status	COMPLETED
Enrolment	410
Start date	2013-10
Completion	2016-03

Conditions

• Cellulitis

Interventions

• Flucloxacillin
• Clindamycin
• Placebo oral capsule

Primary outcomes

• Improvement based on a composite of systemic and local features — Day 5
  Temperature less than 37.5 degrees centigrade, reduction in limb swelling and reduction in skin temperature

Countries

United Kingdom