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NCT01867372
Early Markers of Alzheimer's Disease: Structural and Functional Brain Changes
trial in Alzheimer's Disease in 213 participants. Terminated before completion.
22 September 2014
Quick facts
| Lead sponsor | National Institute on Aging (NIA) |
|---|---|
| Status | Terminated |
| Study type | OBSERVATIONAL |
| Enrollment | 213 |
| Start date | 10 March 2003 |
| Primary completion | 22 September 2014 |
| Estimated completion | 22 September 2014 |
| Sites | 3 locations across United States |
Conditions studied
- Alzheimer's Disease — all drugs for Alzheimer's Disease →
Sponsor
National Institute on Aging (NIA)
Who can join
20 and older, any sex, with Alzheimer's Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Background: \- Participants in the Baltimore Longitudinal Study of Aging are being studied to examine changes in brain structure and function over time, and to determine if these changes can predict the likelihood that an individual will develop thinking and memory impairments such as Alzheimer s disease later in life. Imaging studies and neuropsychological testing have been conducted on current participants, and new participants are being recruited to the study. To develop better treatments and therapies for aging-related memory loss and other disorders, researchers are interested in determining whether early prediction of thinking and memory impairments are accurate and in evaluating factors that affect these predictions. Objectives: \- To use imaging studies and tests of thinking and memory to determine early markers of Alzheimer s disease and other cognitive impairments. Eligibility: \- Current participants and new recruits to the Baltimore Longitudinal Study of Aging. Design: * Participants will be screened with a full medical history and physical examination, as well as blood and urine tests. * Participants will have testing visits as directed by the study researchers. All participants will have tests as part of their an initial enrollment in the study, and may be asked to return yearly, 2 years later, or 4 years later for repeated tests. * At each visit, participants will have brain imaging scans (including magnetic resonance imaging and/or magnetic resonance spectroscopy to measure brain structure and function, and positron emission tomography to study blood flow in the brain) to evaluate brain structure and function. Participants will also take tests of memory and problem-solving skills. * Treatment will not be provided as part of this protocol.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT01867372
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other National Institute on Aging (NIA) trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT01867372 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Institute on Aging (NIA)
- Last refreshed: 12 December 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01867372.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing