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NCT01857401
Development of a Novel Human In Vitro Sarcoidosis Model
trial testing No intervention, observational study only in Sarcoidosis in 60 participants. Completed in 2 February 2017.
2 February 2017
Quick facts
| Lead sponsor | Elliott Crouser MD |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 60 |
| Start date | 19 December 2012 |
| Primary completion | 2 February 2017 |
| Estimated completion | 2 February 2017 |
| Sites | 1 location across United States |
Drugs / interventions tested
- No intervention, observational study only
Conditions studied
- Sarcoidosis — all drugs for Sarcoidosis →
Sponsor
Elliott Crouser MD
Who can join
Adults 18 to 45, any sex, with Sarcoidosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
There is currently no experimental model that accurately represents sarcoidosis. The lack of a useful research model significantly slows progress towards developing new treatments for sarcoidosis. The investigators plan to develop a new model for sarcoidosis research and will test the model to see if it helps us understand how sarcoidosis develops and if it is useful for testing new treatments.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
IL-13-regulated Macrophage Polarization during Granuloma Formation in an In Vitro Human Sarcoidosis Model.
Locke LW, Crouser ED, White P, Julian MW, et al · · 2019 · cited 60× · PMID 30134122 · DOI 10.1165/rcmb.2018-0053oc -
A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent Tuberculosis Infection.
Crouser ED, White P, Caceres EG, Julian MW, et al · · 2017 · cited 56× · PMID 28598206 · DOI 10.1165/rcmb.2016-0321oc -
Leveraging <i>in vitro</i> and pharmacokinetic models to support bench to bedside investigation of XTMAB-16 as a novel pulmonary sarcoidosis treatment.
Offman E, Singh N, Julian MW, Locke LW, et al · · 2023 · cited 10× · PMID 37021060 · DOI 10.3389/fphar.2023.1066454
Verify or expand the search:
- PubMed search for NCT01857401
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Sarcoidosis
Currently open trials in the same condition.
- NCT07498842 — Corticosteroid Tapering in Sarcoidosis · NA · recruiting
- NCT07073963 — Virtual Patient Groups for Sarcoidosis Associated Fatigue · NA · recruiting
- NCT07384897 — Immune Cells Role in Lung Cancer and Their Use in Anticancer Immunotherapies and Inflammatory Lung Disease · NA · recruiting
- NCT06636487 — Expand Pulmonary Rehabilitation to Other Chronic Respiratory Diseases Than COPD · NA · active not recruiting
- NCT06576505 — Immunological Mechanisms in Sarcoidosis · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT01857401 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Elliott Crouser MD
- Last refreshed: 3 November 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01857401.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing