Thyroid Hormone Replacement for Subclinical Hypothyroidism (TRUST) - Subanalysis on Subclinical Hypothyroidism and Depression

NCT01853579 Phase 4 COMPLETED

Mild thyroid failure is a common condition among older adults and has been associated with numerous adverse effects on health, such as cardiovascular disease, cognition disturbances and muscular problems. Mild thyroid failure has also been associated with an increased risk of developing depression. To date, only few studies have investigated the effect of thyroid hormone replacement on depression in patients with mild thyroid failure. This study therefore aims to assess whether thyroid hormone replacement in older adults with mild thyroid failure is associated with a decrease in the presence of depressive symptoms. This study forms a substudy of a large international study on thyroid hormone replacement in older adults with mild thyroid failure (the TRUST study).

Details

Lead sponsor	Insel Gruppe AG, University Hospital Bern
Phase	Phase 4
Status	COMPLETED
Enrolment	426
Start date	2013-03
Completion	2018-04-05

Conditions

• Subclinical Hypothyroidism
• Depression

Interventions

• Levothyroxine
• Placebo

Primary outcomes

• Change from baseline in 15-items Geriatric Depression Scale — At 1 Year

Countries

Netherlands, Switzerland