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Acceptance and Biomarker Response With Oral vs. Intramuscular Supplementation of Vitamin B12 in Primary Care
In this study, biomarker response after supplementation with oral and intramuscular vitamin B12 will be compared in a randomized clinical trial. Electronic compliance monitoring will be used to control for non compliance as a possible confounder in oral treatment. Additionally subjective acceptance in terms of presumed preferences will be compared with oral vs. intramuscular supplementation of vitamin B12 in the view of the patient.
Details
| Lead sponsor | University Hospital, Basel, Switzerland |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 37 |
| Start date | 2013-05 |
| Completion | 2015-12 |
Conditions
- Vitamin B 12 Deficiency
Interventions
- Oral administration of vitamin B12
- i.m. injection of vitamin B12
Primary outcomes
- Biochemical response to vitamin B12 substitution — Day 28
Vitamin B12 associated biomarkers (Vitamin B12, Holotranscobolamin, Homocystein, MCV, hypersegmentated neutrophils)
Countries
Switzerland