NCT01800773: WET

Written Exposure Therapy for Posttraumatic Stress Disorder

Completed NA Last updated 15 January 2019

What this trial tests

NA trial testing Written Exposure Therapy in Posttraumatic Stress Disorder in 192 participants. Completed in 30 April 2018.

Timeline

9 March 2013

Primary endpoint
10 January 2018

30 April 2018

Quick facts

Lead sponsor	Boston University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	192
Start date	9 March 2013
Primary completion	10 January 2018
Estimated completion	30 April 2018
Sites	1 location across United States

Drugs / interventions tested

• Written Exposure Therapy
• Cognitive Processing Therapy

Conditions studied

• Posttraumatic Stress Disorder — all drugs for Posttraumatic Stress Disorder →

Sponsor

Boston University

Who can join

18 and older, any sex, with Posttraumatic Stress Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Although evidence-based treatments for PTSD exist, a significant minority of individuals do not benefit from these treatments and many individuals to not seek treatment, citing barriers such as time commitment and expense of treatment. The goal of the proposed study is to establish an alternative PTSD treatment that is efficacious and efficient.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. A Brief Exposure-Based Treatment vs Cognitive Processing Therapy for Posttraumatic Stress Disorder: A Randomized Noninferiority Clinical Trial.
   Sloan DM, Marx BP, Lee DJ, Resick PA. · · 2018 · cited 157× · PMID 29344631 · DOI 10.1001/jamapsychiatry.2017.4249
2. Long-term treatment gains of a brief exposure-based treatment for PTSD.
   Thompson-Hollands J, Marx BP, Lee DJ, Resick PA, et al · · 2018 · cited 33× · PMID 30144228 · DOI 10.1002/da.22825
3. Predictors of Dropout in Cognitive Processing Therapy for PTSD: An Examination of Trauma Narrative Content.
   Alpert E, Hayes AM, Barnes JB, Sloan DM. · · 2020 · cited 32× · PMID 32800305 · DOI 10.1016/j.beth.2019.11.003
4. Brief treatment for PTSD: A non-inferiority trial.
   Sloan DM, Marx BP, Resick PA. · · 2016 · cited 20× · PMID 27080931 · DOI 10.1016/j.cct.2016.04.003
5. Sudden Gains in Two Trauma-Focused Treatments for Posttraumatic Stress Disorder.
   Sloan DM, Thompson-Hollands J, Hayes AM, Lee DJ, et al · · 2022 · cited 16× · PMID 35227402 · DOI 10.1016/j.beth.2021.08.003
6. Comparing written exposure therapy to Prolonged Exposure for the treatment of PTSD in a veteran sample: A non-inferiority randomized design.
   Sloan DM, Marx BP, Acierno R, Messina M, et al · · 2021 · cited 12× · PMID 33937580 · DOI 10.1016/j.conctc.2021.100764
7. Using Client Narratives to Identify Predictors of Outcome in Written Exposure Therapy and Cognitive Processing Therapy.
   Alpert E, Hayes AM, Barnes JB, Sloan DM. · · 2023 · cited 9× · PMID 36858753 · DOI 10.1016/j.beth.2022.09.002
8. Predictors of dropout in cognitive processing therapy for PTSD: An examination of in-session treatment processes.
   Shayani DR, Canale CA, Sloan DM, Hayes AM. · · 2023 · cited 6× · PMID 37952284 · DOI 10.1016/j.brat.2023.104428