Last reviewed · How we verify
Simplified Selective Digestive Tract Decontamination for the Prevention of ICU Infections in the Setting of High-level Antibiotic Resistance (SDDICU)
A simplified graded gut decontamination protocol combined with rigorous bi-weekly screening and appropriate bacterial prophylaxis, will lead to a 25% reduction in the acquisition of blood stream infections and to a 25% reduction in lower airway colonization with multi drug resistant organisms. There will be no concomitant rise in gram-positive or fungal infection or a surgency of new resistance patterns.
Details
| Lead sponsor | Rambam Health Care Campus |
|---|---|
| Phase | Phase 2/Phase 3 |
| Status | UNKNOWN |
| Enrolment | 2400 |
| Start date | 2013-06 |
| Completion | 2015-07 |
Conditions
- Bacteremia Associated With Intravascular Line
- Ventilator Associated Pneumonia
- Bacteremia
Interventions
- Neomycin Colistin Nystatin Vancomycin
Primary outcomes
- Number of Intensive care acquired infections per 1000 device days — two years
A simplified graded SDD protocol combined with rigorous bi-weekly screening and appropriate bacterial prophylaxis, will lead to a reduction in the acquisition of central venous line blood-stream infections and to a reduction in ventilator associated pneumonia. There will be no concomitant rise in gram-positive or fungal infection or a surgency of new resistance patterns.
Countries
Israel