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NCT01784770: RESCUE-L

Special Investigation Of Azithromycin IV For Legionnaires' Disease (Regulatory Post Marketing Commitment Plan)

Completed Results posted Last updated 30 November 2017
What this trial tests

trial testing Azithromycin IV in Legionnaires' Disease in 21 participants. Completed in 29 July 2016.

Timeline
27 March 2013
Primary endpoint
29 July 2016
29 July 2016

Quick facts

Lead sponsorPfizer
StatusCompleted
Study typeOBSERVATIONAL
Enrollment21
Start date27 March 2013
Primary completion29 July 2016
Estimated completion29 July 2016

Drugs / interventions tested

Conditions studied

Sponsor

Pfizer — full company profile →

Who can join

Eligibility, any sex, with Legionnaires' Disease or Legionella Pneumophila Infections. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Number of Participants With Treatment-Related Adverse Events Primary · 29 days

A treatment-related adverse event was any untoward medical occurrence attributed to Zithromac Intravenous use (and Zithromac Tablets) in a participant who received Zithromac Intravenous use. A treatment-related serious adverse event was a treatment-related adverse event resulting in any of the following outcomes or deemed significant for any other reason: death; initial or prolonged inpatient hospitalization; lifethreatening experience (immediate risk of dying); persistent or significant disability/incapacity; congenital anomaly. Relatedness to Zithromac Intravenous use (and Zithromac Tablets)

Treatment-Related Adverse Event
GroupValue95% CI
Zithromac Intravenous Use (Azithromycin Hydrate)2
Treatment-Related Serious Adverse Event
GroupValue95% CI
Zithromac Intravenous Use (Azithromycin Hydrate)0
Clinical Effectiveness Rate in Participants Secondary · 29 days

Clinical effectiveness rate in participants, which was defined as the percentage of participants who achieved clinical effectiveness over the total number of asssable effectiveness analysis population, was presented along with the corresponding 2-sided 95% CI. Clinical effectiveness of Zithromac Intravenous use (and Zithromac Tablets) was determined by the physician based on clinical symptoms and laboratory findings, and assessed according to the following categories: (1) effective, (2) ineffective, or (3) unassessable.

GroupValue95% CI
Zithromac Intravenous Use (Azithromycin Hydrate)95.276.18 – 99.88

Adverse events — posted to ClinicalTrials.gov

Reporting threshold: 1.0%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Zithromac Intravenous Use (Azithromycin Hydrate)
Serious: 1/21 (5%)
Deaths:

Serious adverse events (1 terms)

ReactionSystemZithromac Intravenous Use …
Gastrointestinal haemorrhageGastrointestinal disorders
Other adverse events (7 terms — click to expand)

ReactionSystemZithromac Intravenous Use …
BradycardiaCardiac disorders
Hepatic function abnormalHepatobiliary disorders
Liver disorderHepatobiliary disorders
Toxic skin eruptionSkin and subcutaneous tissue disorders
Chondrocalcinosis pyrophosphateMusculoskeletal and connective tissue disorders
CrystalluriaRenal and urinary disorders
PollakiuriaRenal and urinary disorders

Most-reported serious reactions: Gastrointestinal haemorrhage.

Data from ClinicalTrials.gov NCT01784770 adverse events section.

Sponsor's own description

To collect retrospectively the efficacy and safety information of azithromycin IV on patients with Legionnaires' disease related to their appropriate use in daily practice.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

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Other trials of Azithromycin IV

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Other Pfizer trials

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Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01784770.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing