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Influence of Cystic Fibrosis on Vascular Endothelial Function at Rest and During Exercise
Perhaps one of the most disturbing aspects of Cystic Fibrosis (CF) is the associated premature death. Oxidative stress has been observed in patients with CF and exercise intolerance has been shown to predict mortality in patients with CF, regardless of how healthy their lungs are. A critical barrier to improving the quality of life and longevity in patients with CF is our lack of knowledge regarding the different reasons why patients with CF cannot exercise to the level of their peers. We have collected preliminary data to support our central hypothesis that oxidative stress contributes to the impairment in blood vessel function at rest and during exercise which ultimately oxygen transport and delivery resulting in exercise intolerance. Exercise is therapeutic medicine for patients with CF and this investigation represents a major breakthrough in the approach to begin understanding the physiological mechanisms which contribute to exercise intolerance in these patients.
Details
| Lead sponsor | Augusta University |
|---|---|
| Phase | Phase 2 |
| Status | COMPLETED |
| Enrolment | 64 |
| Start date | 2011-08 |
| Completion | 2016-06-21 |
Conditions
- Cystic Fibrosis
Interventions
- BH4 5mg
- BH4 20mg
- Antioxidant Cocktail
Primary outcomes
- Percentage Flow-Mediated Dilation (FMD) — pre-treatment Baseline and 2-3 hours post-treatment
Brachial artery FMD induced by reactive hyperemia assessed vascular endothelial function at baseline and several hours after treatment.
Countries
United States