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The Effect of n-3 Fatty Acids and Fish on Glucose and Lipid Metabolism in Subjects With Impaired Glucose Metabolism
The aim of the project is to examine whether the sources of n-3 fatty acids and fish itself differ in their effects on glucose metabolism, lipid metabolism, blood pressure, and serum inflammatory markers. Lipidomic profiles and gene expression will be used for thorough assessment of the possible clinical changes. The study will compare the effects of alpha-linolenic acid containing vegetable oil, fatty fish, lean fish and control diet. The results of this project will help to identify the optimal source of n-3 fatty acids, and reveal the significance of the components of fish other than fatty acids. These data will be useful both nationally and internationally, since highly controlled dietary interventions utilizing new methodology are scarce.
Details
| Lead sponsor | University of Eastern Finland |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 79 |
| Start date | 2012-10 |
Conditions
- Hyperglycemia
Interventions
- Fatty fish
- Lean Fish
- Alpha-linolenic acid
- Control
Primary outcomes
- Glucose metabolism assessed by oral glucose tolerance test and frequently sampled intravenous glucose tolerance test — Baseline and 12 weeks
change in glucose metabolism - Serum lipid profile — Baseline and at 12 weeks
Change in serum lipid profile - Blood pressure — Baseline and 12 weeks
Change in blood pressure - Serum inflammatory markers — baseline and 12 weeks
Change in serum inflammatory markers - Plasma and adipose tissue lipidomic profile — Baseline and 12 weeks
Change in plasma and adipose tissue lipidomic profile - Plasma and urine metabonomics — Baseline and 12 weeks
Change in plasma and urine metabonomics
Countries
Finland