Who is sponsoring NCT01754363?

NCT01754363 is sponsored by DePuy International.

What drugs are being tested in NCT01754363?

Interventions in NCT01754363: Attune Primary Total Knee Replacement.

What condition does NCT01754363 study?

NCT01754363 studies Noninflammatory Degenerative Joint Disease.

Is NCT01754363 still recruiting?

NCT01754363 is currently active, enrolled. Last updated 14 April 2026.

Last reviewed 2026-04-14 · How we verify

NCT01754363

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Survivorship of Attune Primary Total Knee Prosthesis

Active, enrolled NA Last updated 14 April 2026

What this trial tests

NA trial testing Attune Primary Total Knee Replacement in Noninflammatory Degenerative Joint Disease in 1,542 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 February 2013

Primary endpoint
1 February 2030

1 February 2030

Quick facts

Lead sponsor	DePuy International
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	1,542
Start date	1 February 2013
Primary completion	1 February 2030
Estimated completion	1 February 2030
Sites	28 locations across Hong Kong, New Zealand, Malaysia, Belgium, Austria, United Kingdom, Germany, South Korea

Drugs / interventions tested

Attune Primary Total Knee Replacement

Conditions studied

Noninflammatory Degenerative Joint Disease — all drugs for Noninflammatory Degenerative Joint Disease →

Sponsor

DePuy International — full company profile →

Who can join

Adults 22 to 75, any sex, with Noninflammatory Degenerative Joint Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This post-marketing investigation will evaluate the long term (up to 15 years) survivorship of the Attune Primary Knee Prosthesis in patients with non-inflammatory degenerative joint disease. Data from Subjects who receive one of four knee configurations will be pooled to establish a contemporary dataset.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Tibial Baseplate-Cement Interface Debonding in the ATTUNE Total Knee Arthroplasty System.
Torino D, Damsgaard C, Kolessar DJ, Hayes DS, et al · · 2022 · cited 20× · PMID 36164312 · DOI 10.1016/j.artd.2022.06.012
Learning curve with a new primary total knee arthroplasty implant: a multicenter perspective with more than 2000 patients.
Whittaker JP, Dwyer KA, Howard J, Huey V, et al · · 2018 · cited 7× · PMID 30186920 · DOI 10.1016/j.artd.2018.05.004
Comparison of Existing and New Total Knee Arthroplasty Implant Systems From the Same Manufacturer: A Prospective, Multicenter Study.
Hamilton WG, Brenkel IJ, Barnett SL, Allen PW, et al · · 2021 · cited 6× · PMID 34908561 · DOI 10.5435/jaaosglobal-d-21-00136

Verify or expand the search:

Other DePuy International trials

Trials by the same sponsor.

NCT01635166 — Multi-centre Study to Assess the Long-term Performance of the Deltamotion Cup System in Primary Hip Replacement Surgery · Phase 4 · terminated
NCT01418378 — Sigma CR150 Versus Sigma CR Knee RCT · Phase 4 · completed
NCT01134445 — An Electronic Data Capture Study to Assess the Long-term Performance of the DePuy PROXIMA™ Hip in Primary Total Hip Repl · Phase 4 · terminated
NCT00733499 — A Study to Determine the Difference in Low Contact Stress (LCS) Duofix Versus Low LCS Porocoat Knee Systems · NA · completed
NCT00872573 — A Two Centre Study to Assess the Stability and Long-term Performance of the C-Stem™ AMT in a Total Primary Hip Replaceme · Phase 4 · terminated

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01754363 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by DePuy International
Last refreshed: 14 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01754363.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing