NCT01754311 (HAMIL28B) is a clinical trial in HTLV-I Infections, sponsored by University Hospital Center of Martinique.

Who is sponsoring NCT01754311?

NCT01754311 is sponsored by University Hospital Center of Martinique.

What condition does NCT01754311 study?

NCT01754311 studies HTLV-I Infections.

Is NCT01754311 still recruiting?

NCT01754311 is currently completed. Last updated 21 March 2018.

Last reviewed 2018-03-21 · How we verify

NCT01754311: HAMIL28B

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1

Completed Last updated 21 March 2018

What this trial tests

trial in HTLV-I Infections in 155 participants. Completed in 24 June 2014.

Timeline

13 May 2013

Primary endpoint
24 June 2014

24 June 2014

Quick facts

Lead sponsor	University Hospital Center of Martinique
Status	Completed
Study type	OBSERVATIONAL
Enrollment	155
Start date	13 May 2013
Primary completion	24 June 2014
Estimated completion	24 June 2014
Sites	2 locations across Martinique

Conditions studied

HTLV-I Infections — all drugs for HTLV-I Infections →

Sponsor

University Hospital Center of Martinique

Who can join

Adults 18 to 70, any sex, with HTLV-I Infections. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Only 5 to 10% of patients infected with HTLV-1 develop a disease related to infection. The two most serious diseases are adult T-cell leukemia (ATL) and Tropical spastic paraparesis /HTLV-I-associated myelopathy (TSP / HAM). Factors influencing the development of TSP / HAM in the individual HTLV-1 are not yet completely understood. Patients TSP / HAM have a HTLV-1 proviral load (amount of virus) that is 6-10 times higher than seropositive asymptomatic. Various studies have shown that the development of TSP / HAM in the subject HTLV-1 and its rapid evolution is partly attributed to the failure of the immune system that regulates viral replication and expression. It has recently been shown that different versions of Single Nucleotide (human leukocyte antigen) rs12979860, located upstream of the gene for Interleukin 28B (IL28B), influenced the severity of infection with hepatitis C and effectiveness of treatment. By analogy with hepatitis C, a Spanish (Treviño et al., 2012) examined this SNP(single nucleotide polymorphism) in 12 patients TSP / HAM and 29 asymptomatic HIV-positive. CT or TT genotype was statistically more frequent in the group TSP / HAM than in asymptomatic patients (80% versus 20%) and was associated with HTLV-1 proviral load higher. We propose a broader group of patients in our population and Afro-Caribbean, to confirm the results of the latter study was conducted in a predominantly Latin American population.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The Oncoprotein Fra-2 Drives the Activation of Human Endogenous Retrovirus Env Expression in Adult T-Cell Leukemia/Lymphoma (ATLL) Patients.
Tram J, Marty L, Mourouvin C, Abrantes M, et al · · 2024 · PMID 39329701 · DOI 10.3390/cells13181517

Verify or expand the search:

Other University Hospital Center of Martinique trials

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01754311 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital Center of Martinique
Last refreshed: 21 March 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01754311.

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