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SSRI Versus Bupropion in High-Risk Major Depressive Disorder
This study uses functional magnetic resonance imaging (fMRI) to investigate the effects of two different antidepressant medications (Paxil CR versus Wellbutrin XL) on reward processing in depressed patients who have attempted suicide or are currently experiencing suicidal thoughts.
Details
| Lead sponsor | New York State Psychiatric Institute |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 15 |
| Start date | 2010-06 |
| Completion | 2015-03 |
Conditions
- Depression
- Suicidal Ideation
Interventions
- Paroxetine CR for Major Depressive Episode
- Bupropion XL for Major Depressive Episode
Primary outcomes
- Percent Change in Contrast of Parameter Estimates (COPE) — Measured at Baseline (pre-treatment) and Week 8 (post-treatment)
% change in COPE = (Post-treatment COPE - Pre-treatment COPE) / Pre-treatment COPE COPE is measured during Monetary Incentive Delay Task. Task conditions are: Reward= BOLD signal when subject wins 5 cents vs. wins 0 cents Punishment= BOLD signal when subject loses 5cents vs. loses 0 cents
Countries
United States