Who is sponsoring NCT01742702?

NCT01742702 is sponsored by Tampere University.

What drugs are being tested in NCT01742702?

Interventions in NCT01742702: Nitroglycerin 0.25 mg (single dose, no longer given since January 2017), Salbutamol 400 µg (single dose, no longer given since January 2017), L-arginine (10 min infusion, no longer given since January 2017), Liquorice (2 weeks, glycyrrhizin 290-370 mg daily, no longer given since 2012), Small milk casein-derived polypeptides (12 weeks daily, recordings completed 2011), Bisoprolol (5 mg daily for 3 weeks, recordings completed 2011).

What condition does NCT01742702 study?

NCT01742702 studies Primary Hypertension, Secondary Hypertension, Aortic Stenosis, Renal Insufficiency.

Is NCT01742702 still recruiting?

NCT01742702 is currently status unknown. Last updated 19 August 2021.

Last reviewed 2021-08-19 · How we verify

NCT01742702: DYNAMIC

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

HaemoDYNAMICs in Primary and Secondary Hypertension

Status unknown Last updated 19 August 2021

What this trial tests

trial testing Nitroglycerin 0.25 mg (single dose, no longer given since January 2017) in Primary Hypertension in 2,000 participants. Status unknown.

Timeline

25 May 2006

Primary endpoint
31 December 2025

31 December 2025

Quick facts

Lead sponsor	Tampere University
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	2,000
Start date	25 May 2006
Primary completion	31 December 2025
Estimated completion	31 December 2025
Sites	2 locations across Finland

Drugs / interventions tested

Nitroglycerin 0.25 mg (single dose, no longer given since January 2017) — full drug profile →
Salbutamol 400 µg (single dose, no longer given since January 2017) — full drug profile →
L-arginine (10 min infusion, no longer given since January 2017) — full drug profile →
Liquorice (2 weeks, glycyrrhizin 290-370 mg daily, no longer given since 2012)
Small milk casein-derived polypeptides (12 weeks daily, recordings completed 2011)
Bisoprolol (5 mg daily for 3 weeks, recordings completed 2011) — full drug profile →

Conditions studied

Primary Hypertension — all drugs for Primary Hypertension →
Secondary Hypertension — all drugs for Secondary Hypertension →
Aortic Stenosis — all drugs for Aortic Stenosis →
Renal Insufficiency — all drugs for Renal Insufficiency →

Sponsor

Tampere University

Who can join

Adults 18 to 99, any sex, with Primary Hypertension or Secondary Hypertension. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary aim of the present study was to examine the haemodynamic changes in primary hypertension and secondary hypertension (renal diseases, endocrine diseases, obesity-associated hypertension) with a non-invasive haemodynamic measurement protocol utilizing radial pulse wave analysis and whole-body impedance cardiography in both supine position and during head-up tilt. For comparison, haemodynamics of subjects with chronic fatigue syndrome will also be recorded.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Bioactive Candy: Effects of Licorice on the Cardiovascular System.
Deutch MR, Grimm D, Wehland M, Infanger M, et al · · 2019 · cited 59× · PMID 31615045 · DOI 10.3390/foods8100495
Central wave reflection is associated with peripheral arterial resistance in addition to arterial stiffness in subjects without antihypertensive medication.
Wilenius M, Tikkakoski AJ, Tahvanainen AM, Haring A, et al · · 2016 · cited 50× · PMID 27266507 · DOI 10.1186/s12872-016-0303-6
Association of resting heart rate with cardiovascular function: a cross-sectional study in 522 Finnish subjects.
Koskela JK, Tahvanainen A, Haring A, Tikkakoski AJ, et al · · 2013 · cited 50× · PMID 24237764 · DOI 10.1186/1471-2261-13-102
Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women.
Kangas P, Tahvanainen A, Tikkakoski A, Koskela J, et al · · 2016 · cited 23× · PMID 27329447 · DOI 10.1161/jaha.115.002883
Voluntary liquorice ingestion increases blood pressure via increased volume load, elevated peripheral arterial resistance, and decreased aortic compliance.
Hautaniemi EJ, Tahvanainen AM, Koskela JK, Tikkakoski AJ, et al · · 2017 · cited 20× · PMID 28887501 · DOI 10.1038/s41598-017-11468-7
Daily liquorice consumption for two weeks increases augmentation index and central systolic and diastolic blood pressure.
Leskinen MH, Hautaniemi EJ, Tahvanainen AM, Koskela JK, et al · · 2014 · cited 19× · PMID 25153328 · DOI 10.1371/journal.pone.0105607
Changes in hemodynamics associated with metabolic syndrome are more pronounced in women than in men.
Kangas P, Tikkakoski A, Kettunen J, Eräranta A, et al · · 2019 · cited 14× · PMID 31804574 · DOI 10.1038/s41598-019-54926-0
The type of the functional cardiovascular response to upright posture is associated with arterial stiffness: a cross-sectional study in 470 volunteers.
Tahvanainen AM, Tikkakoski AJ, Koskela JK, Nordhausen K, et al · · 2016 · cited 11× · PMID 27216309 · DOI 10.1186/s12872-016-0281-8

Verify or expand the search:

Other recruiting trials for Primary Hypertension

Currently open trials in the same condition.

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Other Tampere University trials

Trials by the same sponsor.

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NCT05766202 — The MOTIVE (Multiparas Overcoming Childbirth Fear Through Intervention and Empowerement) Feasibility Trial · NA · completed
NCT05626543 — The Effect of Mindfulness-based Cognitive Behavior Therapy on Occupational Stress Management · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01742702 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Tampere University
Last refreshed: 19 August 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01742702.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing