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Difference in Efficacy Between Umbilical Cord Mesenchyma Stem Cell Transplantation and Classical Therapy in Liver Cirrhosis Patients
The current treatment methods of liver cirrhosis are limited ,including antiviral therapy,supportive therapy and liver transplantation. Antiviral therapy and Supportive therapy especially the regularly intravenous infusions of plasma or albumin are combined in the clinical classical therapy treatment. In the other hand,umbilical cord mesenchyma stem cell with self and directed differentiation capacity can effectively rescue experimental liver failure and contribute to liver regeneration, which suggests the feasibility of stem cell transplantation therapy. In this study, the safety and efficacy of umbilical cord mesenchyma stem cell transplantation through interventional procedures and classical therapy in patients liver cirrhosis will be evaluated and compared.
Details
| Lead sponsor | General Hospital of Chinese Armed Police Forces |
|---|---|
| Phase | Phase 1/Phase 2 |
| Status | UNKNOWN |
| Enrolment | 60 |
| Start date | 2012-11 |
| Completion | 2014-07 |
Conditions
- Liver Cirrhosis
Interventions
- stem cell transplantation through interventional procedure
- antiviral therapy (lamivudine, other antiviral drugs)
Primary outcomes
- liver volume calculated by MRI — baseline
Instrument:universal 1.5 Tesla superconducting MRI instrument. Slice thickness :2mm. - change from baseline in liver volume calculated by MRI at 6 months — 6 months after treatment
Instrument:universal 1.5 Tesla superconducting MRI instrument. Slice thickness :2mm. - change from baseline in liver volume calculated by MRI at 12 months — 12 months after treatment
Instrument:universal 1.5 Tesla superconducting MRI instrument. Slice thickness :2mm.
Countries
China