Role of the Renin Angiotensin Aldosterone System and Remodeling of the Matrix Cardiac Extra Cellular in the Mechanisms of Transition to Heart Failure in Abdominal Obesity: Prospective Longitudinal Study R2C2 II (R2C2-II)

NCT01716819 NA COMPLETED

R2C2 study has shown that abdominal obesity is associated with a cardiac and vascular remodelling in healthy volunteers. This remodelling is correlated with renin-angiotensin aldosterone system (RAAS) activation and/or systemic fibrosis. R2C2 II study is designed to confirm the hypothesis that RAAS is associated with an early remodelling and implicated in the transition to cardiac failure in abdominal obesity.

Details

Lead sponsor	Central Hospital, Nancy, France
Phase	NA
Status	COMPLETED
Enrolment	101
Start date	2012-11
Completion	2015-03

Conditions

• Obesity, Abdominal

Interventions

• Urine sample
• Blood sample
• Assessment of sleep apnea syndrome
• Electrocardiogram
• Glucose tolerance test
• Echocardiography
• cardiac and abdominal magnetic resonance imaging
• Ambulatory blood pressure monitoring
• Echotracking
• Pulse wave velocity

Primary outcomes

• cardiac extracellular matrix remodelling — 3-7 years
  Initial values of cardiac extracellular matrix remodelling biomarkers and the evolution of biomarkers at 3-7 years

Countries

France