Last reviewed · How we verify
Effect of Acetyl-L-carnitine in Migraine - a Randomized, Double-blind Placebo Controlled Study (ALCAR)
Traditionally, beta blockers have been used for migraine prophylaxis, but in later years also antiepileptic drugs. Contraindications and side effects have to some degree limited their use, and new prophylactics that can be used by most migraine sufferers and with little side effects are in demand. One product that may seem to fulfill these requirements is Acetyl-L-carnitine, which is a dietary supplement and naturally occurs in plants and animals. L-carnitine is necessary for fatty-acid metabolism and energy production. To our knowledge, no placebo-controlled studies have previously evaluated the efficacy of Acetyl-L-carnitine in adults with migraine. The aims of the present study is to evaluate the efficacy of Acetyl-L-carnitine as a prophylaxis in migraine patients
Details
| Lead sponsor | Norwegian University of Science and Technology |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 72 |
| Start date | 2013-04 |
| Completion | 2014-09 |
Conditions
- Migraine
Interventions
- Acetyl-L-carnitine
Primary outcomes
- Headache Days — last 4 weeks
The number of days per 4 weeks with moderate or severe headache lasting ≥ 4 hours or if treated with the patient's usual headache medication (usually a triptan) as the primary endpoint.
Countries
Norway