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A Prospective Study of Red Yeast Rice in Subjects With Clinically Localized Prostate Cancer Undergoing Active Surveillance
Agents that inhibit cholesterol synthesis are being investigated in cancers dependent upon cholesterogenesis. Red yeast rice (RYR), is a reddish-purple fermented rice, containing statins which are known to inhibit cholesterol synthesis. Laboratory studies have also shown that RYR has direct effects on androgen dependent and androgen independent prostate cancer cells, inhibiting their growth. It is thought that RYR may have clinical benefit in those subjects with localized prostate cancer who have chosen to be managed by active surveillance.
Details
| Lead sponsor | Dr. Laurence Klotz |
|---|---|
| Phase | Phase 2 |
| Status | UNKNOWN |
| Enrolment | 60 |
| Start date | 2013-01 |
| Completion | 2017-12 |
Conditions
- Prostate Cancer
Interventions
- Red yeast rice
Primary outcomes
- Expression of Ki-67 and p27 biomarkers — 6 months
Determine effect of red yeast rice therapy on expression of ki67 and p27 biomarkers in a post-treatment biopsy
Countries
Canada