NCT01682915

Structural and Functional Connectivity of Frontostriatal and Frontoparietal Networks as Endophenotypes of ADHD

Completed Last updated 2 September 2021

What this trial tests

trial in Attention Deficit/Hyperactivity Disorder in 240 participants. Completed in 31 July 2015.

Timeline

1 August 2012

Primary endpoint
31 July 2015

31 July 2015

Quick facts

Lead sponsor	National Taiwan University Hospital
Status	Completed
Study type	OBSERVATIONAL
Enrollment	240
Start date	1 August 2012
Primary completion	31 July 2015
Estimated completion	31 July 2015
Sites	1 location across Taiwan

Conditions studied

• Attention Deficit/Hyperactivity Disorder — all drugs for Attention Deficit/Hyperactivity Disorder →

Sponsor

National Taiwan University Hospital

Who can join

Adults 12 to 20, any sex, with Attention Deficit/Hyperactivity Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Attention deficit/hyperactivity disorder (ADHD) is a common, impairing, clinically and genetically heterogeneous neuropsychiatric disorder with lifelong executive dysfunctions. The ultimate goal of this 3-year case-control imaging genomic study with unaffected siblings and typically developing (TD) children as controls is to identify useful imaging endophenotype for ADHD by investigating the structural connectivity, as assessed by diffusion spectrum imaging (DSI), and functional connectivity, as assessed by resting-state fMRI (rsfMRI) of brain regions related to cognitive/executive controls with regards to the ADHD status and the presence of dopamine transporter gene variants (DAT1).

Specific Aims:

1. to validate the executive functions, visuospatial memory, and structural and functional connectivity in frontostriatal, and frontoparietal circuitries as effective neurocognitive endophenotypes;
2. to correlate the data from structural and functional connectivity, neuropsychology, and ADHD core symptoms stratifying by the presence of ADHD, proband-unaffected sibling dyads, and the presence of DAT1 variant; and
3. To investigate reported candidate genes, in addition to DAT1 variant, related to dopamine and noradrenergic neurotransmitter systems in the association with neurocognitive endophenotypes such as DRD1, DRD2, DRD4, DRD5, DBH, MAO-A, ADRA2A, ADRA2C, NET, and COMT.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Regional brain volume predicts response to methylphenidate treatment in individuals with ADHD.
   Chang JC, Lin HY, Lv J, Tseng WI, et al · · 2021 · cited 28× · PMID 33430830 · DOI 10.1186/s12888-021-03040-5
2. White matter endophenotype candidates for ADHD: a diffusion imaging tractography study with sibling design.
   Chiang HL, Hsu YC, Shang CY, Tseng WI, et al · · 2020 · cited 21× · PMID 31115278 · DOI 10.1017/s0033291719001120
3. Visual processing as a potential endophenotype in youths with attention-deficit/hyperactivity disorder: A sibling study design using the counting Stroop functional MRI.
   Fan LY, Shang CY, Tseng WI, Gau SS, et al · · 2018 · cited 20× · PMID 29749060 · DOI 10.1002/hbm.24214
4. Increased Functional Segregation Related to the Salience Network in Unaffected Siblings of Youths With Attention-Deficit/Hyperactivity Disorder.
   Lin HY, Kessler D, Tseng WI, Gau SS. · · 2021 · cited 17× · PMID 31778781 · DOI 10.1016/j.jaac.2019.11.012