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NCT01678703
Randomized Controlled Study: Comparison of Laminaria and Misoprostol for Cervical Preparation Before Second Trimester Surgical Abortion
NA trial testing Laminaria, MedGyn Products, Inc. USA. in Induced; Abortion, Nonmedical in 84 participants. Completed in 1 June 2010.
1 June 2010
Quick facts
| Lead sponsor | Wolfson Medical Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 84 |
| Start date | 1 November 2007 |
| Primary completion | 1 June 2010 |
| Estimated completion | 1 June 2010 |
| Sites | 1 location across Israel |
Drugs / interventions tested
- Laminaria, MedGyn Products, Inc. USA.
- Misoprostol (Misoprostol) — full drug profile →
Conditions studied
- Induced; Abortion, Nonmedical — all drugs for Induced; Abortion, Nonmedical →
Sponsor
Wolfson Medical Center
Who can join
Adults 15 to 45, female only, with Induced; Abortion, Nonmedical. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Initial cervical opening and the need for further dilatation at the start of the procedure
Time frame: 8-12 hours after insersion of laminaria or Misoprostol
The surgical abortion will be performed 8-12 hours after the insertion of laminaria, or after vaginal application of Misoprostol
Sponsor's own description
This study compares the effectiveness of cervical preparation before second trimester abortion using laminaria versus vaginal Misoprostol. The investigators hypothesize that medical preparation of the cervix with vaginal Misoprostol is superior to mechanical preparation using laminaria. The investigators believe that medical preparation makes the procedure easier to perform, equally safe, without addition of pain or discomfort.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
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Cervical preparation for dilation and evacuation at 12 to 24 weeks gestation.
Tufa TH, Stewart F, Meckstroth K, Diedrich JT, et al · · 2025 · PMID 40028776 · DOI 10.1002/14651858.cd007310.pub3
Verify or expand the search:
- PubMed search for NCT01678703
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other Wolfson Medical Center trials
Trials by the same sponsor.
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- NCT07168187 — The Effect of Reflexology on Time to Delivery During Induction of Labor · NA · not yet recruiting
- NCT07168005 — Informative Video Before LMWH Postpartum - Randomized Controlled Trial · NA · not yet recruiting
- NCT07158970 — Home-Ultrasound in Routine High-Risk Care of Patients With Gestational Diabetes Mellitus (GDM) · NA · not yet recruiting
- NCT07064213 — An Informative Video About Perineal Tears During Labor for Anxiety Reduction: A Randomized Controlled Trial · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT01678703 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Wolfson Medical Center
- Last refreshed: 30 August 2012
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01678703.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing