NCT01677793

Developmental Trajectory of Brain Structural Connectivity and Cognitive Function From Childhood to Adulthood

Completed Last updated 2 September 2021

What this trial tests

trial in Brain Structural Connectivity in 140 participants. Completed in 31 December 2014.

Timeline

1 January 2012

Primary endpoint
31 December 2014

31 December 2014

Quick facts

Lead sponsor	National Taiwan University Hospital
Status	Completed
Study type	OBSERVATIONAL
Enrollment	140
Start date	1 January 2012
Primary completion	31 December 2014
Estimated completion	31 December 2014
Sites	1 location across Taiwan

Conditions studied

• Brain Structural Connectivity — all drugs for Brain Structural Connectivity →
• Cognitive Function — all drugs for Cognitive Function →

Sponsor

National Taiwan University Hospital

Who can join

Adults 8 to 21, any sex, with Brain Structural Connectivity or Cognitive Function. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Magnetic resonance imaging (MRI) is a premier modality to investigate structures and functions of human brain. In studies of children and adolescents, noninvasiveness of MRI makes it especially applicable. Developmental trajectory of gray matter volume and cortical thickness has been well studied in western countries. However, significant variability of brain structure has been reported between Chinese and Caucasian, and the variation may also exist in developmental trajectory of the brain. However, the maturation processes of neural fiber tracts in white matter are less understood. Diffusion tensor imaging (DTI), which has been frequently used to investigate the integrity of fibertracts in the literature, is limited in dealing with crossing fibers. Diffusion spectrum imaging (DSI) is a newly developed technique to improve the resolution of crossing fibers, and it is more suitable for detailed tractography assessment. In addition to establishing the template of brain structure (T1 and T2) and structural connectivity of our child, adolescent, and young adult population, the study has the following three aims.

1. To describe gender effect and developmental change of brain volume of different cortical and subcortical regions, thickness of cortex brain, and structural connectivity (e.g., frono-striatal, fronto-pareital, fronto-temporal and fronto-cerebeller tracts and superior longitudinal fasciculus II) across childhood through adolescent to adulthood;
2. To examine the gender effects and developmental change of attention, executive function and visual memory from childhood to adulthood and whether gender moderates these developmental changes; and
3. To correlate the structural connectivity and brain size and neuropsychological function within the same subjects.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Altered white matter tract property related to impaired focused attention, sustained attention, cognitive impulsivity and vigilance in attention-deficit/ hyperactivity disorder.
   Chiang HL, Chen YJ, Lo YC, Tseng WY, et al · · 2015 · cited 68× · PMID 25871496 · DOI 10.1503/jpn.140106
2. Regional brain volume differences between males with and without autism spectrum disorder are highly age-dependent.
   Lin HY, Ni HC, Lai MC, Tseng WI, et al · · 2015 · cited 62× · PMID 26045942 · DOI 10.1186/s13229-015-0022-3