NCT01668446 (sildenafil) is a Phase 4 clinical trial of Sildenafil in Endometrial Preparation, sponsored by farzaneh hojjat.

Who is sponsoring NCT01668446?

NCT01668446 is sponsored by farzaneh hojjat.

What drugs are being tested in NCT01668446?

Interventions in NCT01668446: Sildenafil, estradiol valerat.

What condition does NCT01668446 study?

NCT01668446 studies Endometrial Preparation, Frozen Embryo Transfer.

Is NCT01668446 still recruiting?

NCT01668446 is currently completed. Last updated 11 September 2012.

Last reviewed 2012-09-11 · How we verify

NCT01668446: sildenafil

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Adding Sildenafil to Protocol of Endometrial Preparation in Outcome of Frozen-thawed Embryo Transfer Cycles

Completed Phase 4 Last updated 11 September 2012

What this trial tests

Phase 4 trial testing Sildenafil in Endometrial Preparation in 2 participants. Completed in 1 February 2011.

Timeline

1 September 2009

Primary endpoint
1 September 2009

1 February 2011

Quick facts

Lead sponsor	farzaneh hojjat
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	double
Primary purpose	treatment
Enrollment	2
Start date	1 September 2009
Primary completion	1 September 2009
Estimated completion	1 February 2011
Sites	1 location across Iran

Drugs / interventions tested

Sildenafil (sildenafil) — full drug profile →
estradiol valerat — full drug profile →

Conditions studied

Endometrial Preparation — all drugs for Endometrial Preparation →
Frozen Embryo Transfer — all drugs for Frozen Embryo Transfer →

Sponsor

farzaneh hojjat — full company profile →

Who can join

Adults 20 to 39, female only, with Endometrial Preparation or Frozen Embryo Transfer. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

estimate the result of sildenafil on ultrasonographic endometrial thickness
Time frame: between 2009-2011 (up to 2 years)
Assays: Day 13 of menstrual cycle endometrial thickness estimated with Transvaginal ultrasonographic(arranged in a series every other day), evaluations were performed by a single investigator, If the endometrial thickness is more than 8mm progesterone injected 100 mg intramuscular and Estrogen, progesterone and lh measured in blood sample then after three days embryo transferred.

Sponsor's own description

The target of this study was an estimate the result of sildenafil on ultrasonographic endometrial thickness, endometrial pattern investigation estrogen level on the day of progesterone administration, Implantation rate and chemical pregnancy rate in frozen embryo transfer cycles .

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Sildenafil Supplementation for Women Undergoing Infertility Treatments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Marin L, Andrisani A, Bordin L, Dessole F, et al · · 2021 · cited 6× · PMID 34640363 · DOI 10.3390/jcm10194346

Verify or expand the search:

Other trials of Sildenafil

Trials testing the same drug.

NCT07039760 — Asciminib With or Without Sildenafil for Brain Tumors · EARLY_PHASE1 · not yet recruiting
NCT06800092 — Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment · Phase 2, PHASE3 · not yet recruiting
NCT06954597 — Safety and Tolerability of TOP-N53 Applied on Digital Ulcers in Patients With Systemic Sclerosis · Phase 2 · recruiting
NCT06778330 — The Effect of Combination of Dapagliflozin and Sildenafil in Treatment of Heart Failure Patients With Secondary Pulmonar · NA · completed
NCT06875258 — PEnile ReHABilitation After Nerve Sparing Robot-assisted Radical Prostatectomy for Prostate Cancer 2.0 (PEHAB-II) · Phase 4 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01668446 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by farzaneh hojjat
Last refreshed: 11 September 2012

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01668446.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing