Who is sponsoring NCT01664520?

NCT01664520 is sponsored by Turku University Hospital.

What drugs are being tested in NCT01664520?

Interventions in NCT01664520: Dexmedetomidine infusion.

What condition does NCT01664520 study?

NCT01664520 studies Subarachnoid Hemorrhage, Aneurysm.

Is NCT01664520 still recruiting?

NCT01664520 is currently completed. Last updated 3 February 2017.

Last reviewed 2017-02-03 · How we verify

NCT01664520

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effects of Dexmedetomidine on Cerebral Autoregulation and Cerebral Oxygenation in Subarachnoid Haemorrhage Patients

Completed Phase 1/Phase 2 Last updated 3 February 2017

What this trial tests

Phase 1/Phase 2 trial testing Dexmedetomidine infusion in Subarachnoid Hemorrhage in 10 participants. Completed in 30 December 2016.

Timeline

1 June 2013

Primary endpoint
30 November 2016

30 December 2016

Quick facts

Lead sponsor	Turku University Hospital
Phase	Phase 1/Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	10
Start date	1 June 2013
Primary completion	30 November 2016
Estimated completion	30 December 2016
Sites	1 location across Finland

Drugs / interventions tested

Dexmedetomidine infusion

Conditions studied

Subarachnoid Hemorrhage — all drugs for Subarachnoid Hemorrhage →
Aneurysm — all drugs for Aneurysm →

Sponsor

Turku University Hospital

Who can join

Adults 18 to 80, any sex, with Subarachnoid Hemorrhage or Aneurysm. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Change in autoregulation, ICP and cerebral oxygenation
Time frame: 2, 4 and 6 hours
Autoregulation is assessed using transcranial doppler (TCD) and ICP amplitude analysis. ICP and cerebral oxygenation are part of standard multimodal monitoring and these are continuously monitored and recorded.

Sponsor's own description

The purpose of this study is to investigate how dexmedetomidine affects static and dynamic autoregulation, intracranial pressure (ICP) and cerebral oxygenation in aneurysmal subarachnoid haemorrhage (SAH) patients.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

[Guidelines for diagnosis and management of aneurysmal subarachnoid hemorrhage: top issues and prospective].
Zhang JM. · · 2015 · cited 5× · PMID 26555410 · DOI 10.3785/j.issn.1008-9292.2015.07.01
Dexmedetomidine Improves BBB and Neuronal Damage in Subarachnoid Hemorrhage by Repressing S100A4-Mediated Astrocytic Reactivity.
Yin J, Xu Q, Lu K, Wu J, et al · · 2026 · PMID 42064389 · DOI 10.1177/15593258261445031

Verify or expand the search:

Other trials of Dexmedetomidine infusion

Trials testing the same drug.

NCT07434310 — Use of Dexmedetomidine to Improve Pain Control and Recovery After Laparocopic-Assisted Bowel Surgery in Adults · Phase 3 · not yet recruiting
NCT06738043 — Dexmedetomidine Versus Ketamine as Adjuvants in Bariatric Surgery · NA · not yet recruiting
NCT06970678 — Combining Dexmedetomidine Infusion and Paragastric Autonomic Neural Block to Enhance Postoperative Recovery in Patients · Phase 1, PHASE2 · recruiting
NCT06970626 — Quality of Recovery in Laparoscopic Sleeve Gastrectomy Using Dexmedetomidine Infusion Versus Laparoscopic TAP Block in C · Phase 2, PHASE3 · recruiting
NCT05283408 — The Clinical Study of Dexmedetomidine and Esketamine Combined Infusion Undergoing Modified Radical Mastectomy · NA · completed

Other recruiting trials for Subarachnoid Hemorrhage

Currently open trials in the same condition.

NCT06797765 — Optical Coherence Tomography Angiography in Neurological Disease · recruiting
NCT06866210 — Risk Analysis of Intracranial Aneurysm Rupture Through Social Determinants of Health · active not recruiting
NCT06797752 — Effect of the Stellate Ganglion Block on the Retinal Microcirculation · recruiting
NCT06192342 — Ventilatory Parameters in Acute Neurological Injury · recruiting
NCT04459806 — Intracranial PrEssure Time dOse (ImPETO) · recruiting

Other Turku University Hospital trials

Trials by the same sponsor.

NCT07488494 — Effective Implementation of the Physical Activity and Motor Skills Intervention for 3-6-year-old Children With Cancer (E · NA · not yet recruiting
NCT07316868 — Neuroprotective Effect of Mild Hypothermia Versus Normothermia During Cardiopulmonary Bypass of Coronary Artery Surgery · NA · not yet recruiting
NCT07306000 — Pilot Study: Effects of CCP Intervention on NICU Environment and Preterm Infants Development · NA · recruiting
NCT07272824 — Usability Study of Gestational and Postpartum Weight Management Program · recruiting
NCT07310472 — Administration of the Nasal Influenza Vaccine to Children in Daycare or at a Healthcare Facility · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01664520 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Turku University Hospital
Last refreshed: 3 February 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01664520.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing