NCT01661582: MIDAS

Myocardial Ischaemia After Exposure to Diesel Exhaust

Completed NA Last updated 9 May 2024

What this trial tests

NA trial testing CT/PET Myocardial Perfusion Imaging using O-15 water in Coronary Heart Disease in 28 participants. Completed in 13 February 2015.

Timeline

20 September 2012

Primary endpoint
13 February 2015

13 February 2015

Quick facts

Lead sponsor	University of Edinburgh
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	basic science
Enrollment	28
Start date	20 September 2012
Primary completion	13 February 2015
Estimated completion	13 February 2015
Sites	1 location across United Kingdom

Drugs / interventions tested

• CT/PET Myocardial Perfusion Imaging using O-15 water
• Coronary blood flow measured by doppler echocardiography

Conditions studied

• Coronary Heart Disease — all drugs for Coronary Heart Disease →

Sponsor

University of Edinburgh

Who can join

Adults 18 to 60, male only, with Coronary Heart Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Exposure to particulate air pollution is associated with increases in cardiovascular mortality and morbidity. The pathophysiological mechanisms underlying this observation are emerging, and exposure to particulate air pollution has been shown to result in increases in blood pressure and arterial tone, impaired vascular function and an increased tendency for blood to clot as well as an increase in atherosclerotic plaque burden. Recent evidence from panel studies and controlled exposure studies have suggested an increase in myocardial ischaemia (a reduction in blood flow to the heart) following exposure. In this study we aim to investigate directly myocardial (heart) blood flow following exposure to diesel exhaust (as a model of urban air pollution) using CT/PET myocardial perfusion imaging in male patients with stable coronary disease and healthy male controls. We hypothesize that following exposure to dilute diesel exhaust:

1. Myocardial blood flow will be reduced
2. Coronary flow reserve will be impaired
3. The magnitude of impairment will be higher in patients with coronary disease as compared to healthy controls

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Controlled exposures to air pollutants and risk of cardiac arrhythmia.
   Langrish JP, Watts SJ, Hunter AJ, Shah AS, et al · · 2014 · cited 30× · PMID 24667535 · DOI 10.1289/ehp.1307337