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Spectrum of Gastrointestinal Microbiota in Patients With IBS-D Before and After Treatment With VSL#3.
Aim To compare changes in gut microbiota of IBS patients and healthy controls using next generation sequencing method like Illumina sequencing based on 16S rDNA profiling. The major objectives of the study are: To characterize type of bacterial species and compare diversity of the host's gut microbiota in 20 Irritable bowel syndrome (IBS) patients with 16 healthy controls (HCs) using high through put culture-independent method like Illumina sequencing. To study modulation of gut microbiota profile after treatment with probiotics (VSL #3) for 8 weeks. To study the improvement of symptoms after modulation of gut microbiota with probiotics (VSL #3) for more than 8 weeks.
Details
| Lead sponsor | Asian Institute of Gastroenterology, India |
|---|---|
| Phase | Phase 4 |
| Status | UNKNOWN |
| Enrolment | 40 |
| Start date | 2012-08 |
| Completion | 2012-12 |
Conditions
- Irritable Bowel Syndrome
Interventions
- VSL#3
Primary outcomes
- Improvement of symptoms after modulation of gut microbiota with probiotic, VSL#3 — 8 wks
To study modulation of gut microbiota profile after treatment with probiotics (VSL #3) for 8 weeks.
Countries
India