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Comparison of Effects of Nutritional Doses Vitamin K1 and K2 on Carboxylation
The effects of two vitamin K-forms on carboxylation of the vitamin K-dependent proteins osteocalcin and matrix-gla protein will be compared after supplementing these vitamins in a nutritional dose range. The investigators hypothesized that MK-7 is more effective than K1 at a dose comparable to the RDA of vitamin K.
Details
| Lead sponsor | Maastricht University Medical Center |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 81 |
| Start date | 2011-03 |
| Completion | 2011-09 |
Conditions
- Bone Health
- Vascular Health
Interventions
- Placebo
- Vitamin K1-capsules
- Vitamin K2-capsules
Primary outcomes
- carboxylation of osteocalcin — 12 weeks
The primary objective of the study is to compare the effects of K1 and MK-7 on circulating ucOC levels after supplementing these vitamins at a nutritional dose.
Countries
Netherlands