Who is sponsoring NCT01630213?

NCT01630213 is sponsored by Massachusetts General Hospital.

What drugs are being tested in NCT01630213?

Interventions in NCT01630213: Vitamin D3 + fish oil/fish oil placebo, Vitamin D3 placebo + fish oil/fish oil placebo.

What condition does NCT01630213 study?

NCT01630213 studies Cardiovascular Disease.

Is NCT01630213 still recruiting?

NCT01630213 is currently completed. Last updated 6 April 2022.

Last reviewed 2022-04-06 · How we verify

NCT01630213: VITAL-Echo

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of Vitamin D Supplementation on Cardiac Structure and Function

Completed NA Last updated 6 April 2022

What this trial tests

NA trial testing Vitamin D3 + fish oil/fish oil placebo in Cardiovascular Disease in 1,025 participants. Completed in 30 June 2021.

Timeline

1 July 2010

Primary endpoint
11 April 2016

30 June 2021

Quick facts

Lead sponsor	Massachusetts General Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	factorial
Masking	quadruple
Primary purpose	prevention
Enrollment	1,025
Start date	1 July 2010
Primary completion	11 April 2016
Estimated completion	30 June 2021
Sites	1 location across United States

Drugs / interventions tested

Vitamin D3 + fish oil/fish oil placebo
Vitamin D3 placebo + fish oil/fish oil placebo

Conditions studied

Cardiovascular Disease — all drugs for Cardiovascular Disease →

Sponsor

Massachusetts General Hospital

Who can join

50 and older, any sex, with Cardiovascular Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is a randomized clinical trial in 20,000 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or fish oil (1 gram of omega-3 fatty acids) reduces the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses. This ancillary study (VITAL-Echo) is being conducted among participants in VITAL and will examine whether vitamin D compared to placebo: (1) reduces left ventricular (LV) mass in elderly individuals as measured with 2-dimensional echocardiography and (2) improves LV systolic and diastolic function as measured with tissue Doppler echocardiography.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.
Abdelhamid AS, Brown TJ, Brainard JS, Biswas P, et al · · 2020 · cited 203× · PMID 32114706 · DOI 10.1002/14651858.cd003177.pub5
Impact of Vitamin D3 Versus Placebo on Cardiac Structure and Function: A Randomized Clinical Trial.
Chandra A, Picard MH, Huang S, Gupta DK, et al · · 2022 · cited 9× · PMID 36285795 · DOI 10.1161/jaha.121.025008

Verify or expand the search:

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Other Massachusetts General Hospital trials

Trials by the same sponsor.

NCT03585946 — Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Necrolysis · withdrawn
NCT07214831 — A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerg · NA · not yet recruiting
NCT06686901 — A Randomized Controlled Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior · NA · not yet recruiting
NCT05854212 — Behavioral Economics to Implement Nutrition Ranking in Food Pantries · NA · not yet recruiting
NCT07323446 — The MIND Study: The MGH/MIT Investigation of NAC on Dysregulation · EARLY_PHASE1 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01630213 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Massachusetts General Hospital
Last refreshed: 6 April 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01630213.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing