Stop Hypernatremia, Use Metolazone for Aggressive, Controlled, Effective Diuresis (SHUM)

NCT01617798 NA WITHDRAWN

Patients who are on mechanical ventilation in an intensive care unit often require diursis as part of their pre-extubation regimen. The drug of choice for diuresis has traditionally been furosemide. However, this drug cause hypernatremia (a rise in serum sodium) in a significant proportion of patients. Hypernatremia is traditionally treated by providing free water supplementation to the patient. This strategy creates a vicious and unproductive cycle of giving free water, and then diuresing it off. We propose a strategy for breaking this cycle by using a second diuretic-- metolazone-- which has a tendency to rid the body of more sodium, thereby minimizing hypernatremia.

Details

Lead sponsor	Oregon Health and Science University
Phase	NA
Status	WITHDRAWN
Start date	2012-06
Completion	2013-06

Conditions

• Respiratory Failure
• Volume Overload
• Hypernatremia

Interventions

• Supplemental metolazone diuresis
• Placebo Comparator: Control-- furosemide (lasix) only

Primary outcomes

• Fluid balance — 24, 36, 48, and 72 hours after either protocol is initiated
  Differences in fluid balance (total net liters negative from the time diuresis is initiated) between the study group and control group at the following intervals: 24, 36, 48, and 72 hours after either protocol is initiated.

Countries

United States