NCT01607931

The Effects of Acute Exercise on Glucose Kinetics, Beta-cell Function and the Incretin Effect in Subjects Representative of the Whole Glucose Tolerance Continuum

Completed NA Last updated 11 August 2016

What this trial tests

NA trial testing Exercise in Type 2 Diabetes in 12 participants. Completed in 1 July 2016.

Timeline

1 January 2013

Primary endpoint
1 April 2016

1 July 2016

Quick facts

Lead sponsor	Rigshospitalet, Denmark
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	basic science
Enrollment	12
Start date	1 January 2013
Primary completion	1 April 2016
Estimated completion	1 July 2016
Sites	1 location across Denmark

Drugs / interventions tested

• Exercise

Conditions studied

• Type 2 Diabetes — all drugs for Type 2 Diabetes →

Sponsor

Rigshospitalet, Denmark

Who can join

Adults 18 to 60, any sex, with Type 2 Diabetes. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

• Glucose tolerance
  Time frame: Plasma glucose will be measured at 10 minute intervals during the OGTT (3 hours) immediately following the period of rest or exercise
• Incretin effect
  Time frame: Plasma insulin and C-peptide will be measured at 10 minute intervals during the OGTT (3 hours) and isoglycemic clamp (3 hours) immediately following the period of rest or exercise

Sponsor's own description

Human volunteers will be stratified by oral glucose tolerance status: normal glucose tolerant, impaired glucose tolerant, and type 2 diabetic. All subjects will undergo 4 experimental trials: \[1\] an oral glucose tolerance test (OGTT) combined with infused and ingested stable isotopes of glucose to assess glucose kinetics. \[2\] a 1 hour bout of cycling exercise at 50% of maximum power output, immediately followed by the same OGTT combined with stable isotope glucose tracers used in trial 1. \[3\] an isoglycemic clamp to match the plasma glucose profile measured in trial 1. \[4\] a 1 hour bout of cycling exercise at 50% of maximum power output, immediately followed by an isoglycemic clamp to match the plasma glucose profile measured in trial 2.

Exercise-induced changes in oral glucose tolerance, glucose kinetics, insulin and glucagon secretion, and the incretin effect will be examined. The exercise responses will be compared between the subjects groups of different glucose tolerance status.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. The immediate effects of a single bout of aerobic exercise on oral glucose tolerance across the glucose tolerance continuum.
   Knudsen SH, Karstoft K, Pedersen BK, van Hall G, et al · · 2014 · cited 40× · PMID 25168869 · DOI 10.14814/phy2.12114