Effect of Aminophylline on Contrast Induced Acute Kidney Injury in Patients With Acute Myocardial Infarction Treated With Primary Angioplasty

NCT01594489 Phase 4 COMPLETED

The purpose of this study is to determine whether additional therapy with Aminophylline to hydration with sodium bicarbonate and administration of N-acetylcysteine is more effective to prevent contrast induced acute kidney injury in patients undergoing primary coronary intervention for acute ST elevation myocardial infarction.

Details

Lead sponsor	Ospedale Misericordia e Dolce
Phase	Phase 4
Status	COMPLETED
Enrolment	250
Start date	2009-01
Completion	2012-09

Conditions

• Acute Kidney Injury

Interventions

• Aminophylline
• Hydration plus N-acetylcisteine

Primary outcomes

• Incidence of Contrast-Induced Acute Kidney Injury — 3 days
  Contrast-Induced Acute Kidney Injury is defined as an increase in serum creatinine of \>=25% or 0.5 mg/dL over the baseline value within 3 days after the administration of the contrast medium

Countries

Italy