NCT01591629 is a EARLY_PHASE1 clinical trial of Naloxone in Healthy, sponsored by Yale University.

Who is sponsoring NCT01591629?

NCT01591629 is sponsored by Yale University.

What drugs are being tested in NCT01591629?

Interventions in NCT01591629: Naloxone, Delta-9-THC, Placebo.

Is NCT01591629 still recruiting?

NCT01591629 is currently completed. Last updated 9 March 2022.

Last reviewed 2022-03-09 · How we verify

NCT01591629

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effects of ∆-9-THC and Naloxone in Humans

Completed EARLY_PHASE1 Last updated 9 March 2022

What this trial tests

EARLY_PHASE1 trial testing Naloxone in Healthy in 6 participants. Completed in 1 June 2012.

Timeline

4 November 2011

Primary endpoint
1 June 2012

1 June 2012

Quick facts

Lead sponsor	Yale University
Phase	EARLY_PHASE1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	basic science
Enrollment	6
Start date	4 November 2011
Primary completion	1 June 2012
Estimated completion	1 June 2012
Sites	1 location across United States

Drugs / interventions tested

Naloxone (NALOXONE) — full drug profile →
Delta-9-THC — full drug profile →
Placebo

Conditions studied

Healthy — all drugs for Healthy →

Sponsor

Yale University

Who can join

Adults 18 to 55, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this project is to examine the effects of mu-opiate antagonism on the rewarding and reinforcing effects of delta-9-tetrahydrocannabinol (THC), the main psychoactive ingredient of cannabis.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The Use of Psychedelics in the Treatment of Medical Conditions: An Analysis of Currently Registered Psychedelics Studies in the American Drug Trial Registry.
Kurtz JS, Patel NA, Gendreau JL, Yang C, et al · · 2022 · cited 19× · PMID 36259015 · DOI 10.7759/cureus.29167

Verify or expand the search:

Other trials of Naloxone

Trials testing the same drug.

NCT04975334 — Opioid Antagonism in Hypogonadotropic Hypogonadism · Phase 1 · completed
NCT05886712 — Improving Access to Naloxone to Prevent Opioid Overdose Deaths (SAIA-Naloxone) · NA · active not recruiting
NCT05490134 — RM1 Project 1 - tAN Naloxone · EARLY_PHASE1 · recruiting
NCT04975347 — Opioid Antagonism in Individuals Ascertained Through the Partners HealthCare Biobank · Phase 1 · completed
NCT05360030 — Mechanism of Analgesic Effect on Prolonged Continuous Theta Burst Stimulation · NA · completed

Other recruiting trials for Healthy

Currently open trials in the same condition.

NCT06707207 — Predicting Future Errors During Skill Performance · recruiting
NCT07169630 — PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI) · Phase 1 · recruiting
NCT07499414 — The Effects of the Bile Acid Supplement, 7-keto Lithocholic Acid, on Human Gut Microbiota and Risk Factors for Disease. · NA · recruiting
NCT07496697 — Effects of Electroacupuncture at NP82 and SP15 on Bowel Motility in Healthy Subjects · NA · recruiting
NCT06431932 — Pilot Trial of Fisetin in Healthy Volunteers and Older Patients With Multimorbidity · Phase 1, PHASE2 · recruiting

Other Yale University trials

Trials by the same sponsor.

NCT06900998 — Pilot Study: Effects of Nimodipine on Alcohol Drinking · Phase 2 · not yet recruiting
NCT04910984 — Developing a Chatbot to Promote HIV Testing · NA · not yet recruiting
NCT07458087 — Accuracy of the Accuro 3S · NA · not yet recruiting
NCT07398404 — A Multiple Health Behavior Change (MHBC) Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Pa · Phase 1, PHASE2 · not yet recruiting
NCT07305324 — Improving Liver Fibrosis Diagnosis in Primary Care Using FibroX AI · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01591629 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Yale University
Last refreshed: 9 March 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01591629.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing