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NCT01581450
Evaluation of Antihyperalgesic and Analgesic Effects of 35% Nitrous Oxide in a Human Model of Electrically Evoked Hyperalgesia and Pain
Phase 1 trial testing Nitrous Oxide in Hyperalgesia in 20 participants. Completed in 1 April 2012.
1 April 2012
Quick facts
| Lead sponsor | Air Liquide Santé International |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 20 |
| Start date | 1 January 2012 |
| Primary completion | 1 April 2012 |
| Estimated completion | 1 April 2012 |
| Sites | 2 locations across Germany |
Drugs / interventions tested
- Nitrous Oxide (NITROUS OXIDE) — full drug profile →
- Nitrous Oxide (NITROUS OXIDE) — full drug profile →
Conditions studied
- Hyperalgesia — all drugs for Hyperalgesia →
Sponsor
Air Liquide Santé International — full company profile →
Who can join
Adults 18 to 40, male only, with Hyperalgesia. Healthy volunteers can join.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Hyperalgesia
Time frame: at T0, T10, T25, T40, T55, T70, T95, T110, T125, T140 and T155 minutes at each experimental session which will last half day
\- Hyperalgesia will be assessed by using a metal rod,(in unit cm).
Sponsor's own description
Evaluation of the effects of 35%/15%/50% N2O/N2/O2 mixtures on the area of hyperalgesia induced by remifentanil in the CCES (Continuous Cutaneous Electrical Stimulation) model in 20 healthy volunteers. The duration of participation for each volunteer is expected to be around 9 weeks with the performance of 4 experimental session 2 weeks apart. The selection visit will last half a day; each experimental session will last half a day; the study end will last 2 hours maximum.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT01581450
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Nitrous Oxide
Trials testing the same drug.
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- NCT04305158 — Colonoscopy Using Nitrous Oxide- A Pilot Study in the USA · EARLY_PHASE1 · completed
- NCT04378426 — Nitrous Oxide for PTSD · Phase 2 · terminated
- NCT04884893 — Effect of Nitrous Oxide on EEG · Phase 1 · completed
Other recruiting trials for Hyperalgesia
Currently open trials in the same condition.
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- NCT05603702 — STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis · Phase 1 · recruiting
- NCT05357157 — Electroacupuncture Pain Treatment, Mechanical Hyperalgesia, Quality of Life & Expression of Mu+ B Cells in Fibromyalgia · recruiting
Other Air Liquide Santé International trials
Trials by the same sponsor.
- NCT05793645 — Clinical Investigation to Assess the Feasibility of a New Diabetes Management Program · NA · unknown
- NCT05246449 — Evaluate the Benefit of an Individualised Treatment Plan (VitalCare) VS SOC in OSA Patients Treated With CPAP/APAP · NA · completed
- NCT04635280 — Evaluation of Satisfaction Regarding Home Healthcare Provider (HHP) Management of Type 1 Diabetic Patients Using a Close · NA · completed
- NCT04615078 — Study Evaluating Telemonitoring and Experimentation in Telemedicine for the Improvement of Healthcare Pathways (ETAPES P · NA · completed
- NCT04233229 — Evaluation of a Closed-loop Insulin Delivery System at Home With Tailored Home Care Services in Poorly Controlled Type 2 · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT01581450 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Air Liquide Santé International
- Last refreshed: 10 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01581450.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing