NCT01578122: CELEST

Elastic Compression Stockings for Prevention of Post-thrombotic Syndrome

Completed NA Last updated 22 January 2020

What this trial tests

NA trial testing 25mmHg ECS in Deep Vein Thrombosis in 350 participants. Completed in 28 June 2019.

Timeline

29 June 2012

Primary endpoint
28 June 2019

28 June 2019

Quick facts

Lead sponsor	Laboratoires Innothera
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	350
Start date	29 June 2012
Primary completion	28 June 2019
Estimated completion	28 June 2019
Sites	57 locations across France

Drugs / interventions tested

• 25mmHg ECS
• 35 mmHg ECS

Conditions studied

• Deep Vein Thrombosis — all drugs for Deep Vein Thrombosis →
• Post-thrombotic Syndrome — all drugs for Post-thrombotic Syndrome →

Sponsor

Laboratoires Innothera

Who can join

18 and older, any sex, with Deep Vein Thrombosis or Post-thrombotic Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Post thrombotic syndrome (PTS) is a frequent and burdensome complication of proximal deep-vein thrombosis.Therapeutic options for PTS are limited and mainly rely on its prevention. Therapeutic trials evidenced that elastic compression stockings (ECS) applying 30-40mmHg of pressure at the ankle reduced the rate of PTS by 50%. Although ECS are unlikely to cause harm, in clinical practice, compliance to this treatment appears to be low as ECS may be difficult to apply and to wear.

ECS with a lighter compression strength (20-30mmHg) might be easier to apply and be more comfortable. This could favor a better compliance.

CELEST is a randomized, multicentre, double-blind trial which aims to determine whether ECS applying 25mmHg of targeted pressure at the ankle are non inferior to ECS applying 35mmHg of targeted pressure at the ankle

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

1. Prevention and Management of the Post-Thrombotic Syndrome.
   Makedonov I, Kahn SR, Galanaud JP. · · 2020 · cited 51× · PMID 32230912 · DOI 10.3390/jcm9040923
2. Compression therapy for prevention of post-thrombotic syndrome.
   Appelen D, van Loo E, Prins MH, Neumann MH, et al · · 2017 · cited 36× · PMID 28950030 · DOI 10.1002/14651858.cd004174.pub3
3. 25 mm Hg versus 35 mm Hg elastic compression stockings to prevent post-thrombotic syndrome after deep vein thrombosis (CELEST): a randomised, double-blind, non-inferiority trial.
   Galanaud JP, Genty-Vermorel C, Barrellier MT, Becker F, et al · · 2022 · cited 10× · PMID 36455606 · DOI 10.1016/s2352-3026(22)00247-2
4. Compression stockings to prevent postthrombotic syndrome: Literature overview and presentation of the CELEST trial.
   Galanaud JP, Genty-Vermorel C, Rolland C, Comte A, et al · · 2020 · cited 6× · PMID 33313464 · DOI 10.1002/rth2.12445
5. Impact of adherence to elastic compression stockings on efficacy to prevent postthrombotic syndrome: a prespecified analysis of the Compression Elastique Evaluation du Syndrome post Thrombotique study.
   Galanaud JP, Genty-Vermorel C, Terriat B, Stansal A, et al · · 2026 · PMID 41969542 · DOI 10.1016/j.rpth.2026.103399
6. ABSTRACTS
   · 2021