NCT01576276 is a NA clinical trial of Integrated MR-PET scan in Healthy Controls, sponsored by Massachusetts General Hospital.

Who is sponsoring NCT01576276?

NCT01576276 is sponsored by Massachusetts General Hospital.

What drugs are being tested in NCT01576276?

Interventions in NCT01576276: Integrated MR-PET scan, Ketorolac.

What condition does NCT01576276 study?

NCT01576276 studies Healthy Controls.

Is NCT01576276 still recruiting?

NCT01576276 is currently completed. Last updated 29 May 2018.

Are results published for NCT01576276?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2018-05-29 · How we verify

NCT01576276

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Brain Imaging Study of Opioid (Morphine) and Non-opioid (Ketorolac) Conditioning Effects

Completed NA Results posted Last updated 29 May 2018

What this trial tests

NA trial testing Integrated MR-PET scan in Healthy Controls in 51 participants. Completed in 1 February 2017.

Timeline

1 April 2012

Primary endpoint
1 February 2017

1 February 2017

Quick facts

Lead sponsor	Massachusetts General Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	other
Enrollment	51
Start date	1 April 2012
Primary completion	1 February 2017
Estimated completion	1 February 2017
Sites	1 location across United States

Drugs / interventions tested

Integrated MR-PET scan
Ketorolac (KETOROLAC) — full drug profile →

Conditions studied

Healthy Controls — all drugs for Healthy Controls →

Sponsor

Massachusetts General Hospital

Who can join

Adults 21 to 50, any sex, with Healthy Controls. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

fMRI Signal Changes
Time frame: one day
Obtain information about brain activity, including BOLD (Blood-oxygen-level dependent) signal, using an fMRI system. Data analysis was applied using SPM 12 with a standard pipeline.
Pain Ratings
Time frame: One day
The primary endpoint was the morphine and ketorolac conditioning effects as indicated by subjective pain rating changes between pain only (a control condition with no injection of glucose, but subject's did see an image of an hour glass displaying how much time they had before receiving a painful stimulus) and pain+glucose (subjects received a glucose injection accompanied by an injection schemati

Sponsor's own description

Healthy right-handed volunteers aged 21 to 50 needed for a research study of the effects of morphine and ketorolac on brain activity in response to pain stimuli as measured by functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET). Study will be conducted on six separate days not requiring an overnight stay in the hospital.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

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Other Massachusetts General Hospital trials

Trials by the same sponsor.

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NCT05854212 — Behavioral Economics to Implement Nutrition Ranking in Food Pantries · NA · not yet recruiting
NCT07323446 — The MIND Study: The MGH/MIT Investigation of NAC on Dysregulation · EARLY_PHASE1 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01576276 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Massachusetts General Hospital
Last refreshed: 29 May 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01576276.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing