A Prospective, Randomized, Double-blind Study of the Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Inferior Alveolar Nerve Blocks.

NCT01574807 Phase 4 COMPLETED Results posted

The inferior alveolar nerve block (shot) is the most frequently used injection technique for achieving local anesthesia (numbness) for the teeth in the lower jaw. However, this injection does not always result in successful pulpal (tooth) anesthesia (patient felt pain). No study has combined mepivacaine and lidocaine anesthetics (numbing solutions) for this type of injection (shot). The investigators propose to compare an injection of mepivacaine followed by lidocaine to an injection of lidocaine followed by lidocaine to determine if there is a difference in effectiveness.

Details

Lead sponsor	Ohio State University
Phase	Phase 4
Status	COMPLETED
Enrolment	100
Start date	2012-05
Completion	2013-05

Conditions

• Pain

Interventions

• mepivacaine + lidocaine followed by lidocaine +lidocaine
• lidocaine + lidocaine followed by mepivacaine + lidocaine

Primary outcomes

• Number of Participants Achieving Pulpal Anesthesia Success. — 60 minutes per injection sequence.
  An electric pulp tester will be used to test the lower jaw teeth (molars, premolars, and incisors) for anesthesia (numbness) in 4-minute time cycles for 60 minutes. Measurements of less than 80 on the EPT is considered not numb (anesthesia failure). Readings of 80 equate to anesthetic success.

Countries

United States