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Peripheral Blood Dendritic Cells and Periodontitis
The investigators hypothesize that blood dendritic cells harbor pathogens from the oral cavity in chronic periodontitis and disseminate these pathogens to atherosclerotic plaques.
Details
| Lead sponsor | Augusta University |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 18 |
| Start date | 2012-03 |
| Completion | 2014-09 |
Conditions
- Chronic Periodontitis
Interventions
- Oral Antibiotic and Oral Rinse
- Standard Treatment
Primary outcomes
- Frequency of Blood Dendritic Cells From Baseline — 30 days
The frequency of blood dendritic cells, i.e. % CCR6+CD1a+ DCs by flow cytometry 30 days after treatment with 7 day regimen of antibiotics, mouthrinse therapy and scaling and root planing (SRP) will be compared to those who did not receive the antibiotics, but did receive mouthrinse and scaling and root planing (SRP)
Countries
United States