Last reviewed · How we verify
The Biological Basis of Individual Variation in Social Cooperation
The project has three overall objectives. The first is to determine whether and how administration of intranasal oxytocin (OT) and intranasal vasopressin (AVP) influence cooperative decision-making and neural responses to cooperative and un-cooperative social interactions. The second is to determine whether and how intranasal vasopressin influences subjective evaluations of and neural responses to same and opposite-sex face stimuli and to determine if any of these effects persist beyond the period of AVP exposure. The third objective is to determine if intranasal OT influences empathy-related behavior and associated brain activity.
Details
| Lead sponsor | Emory University |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 707 |
| Start date | 2008-04 |
| Completion | 2016-11 |
Conditions
- Healthy
Interventions
- Intranasal Oxytocin (OT) 24 IU
- Intranasal Vasopressin (AVP)
- Intranasal Placebo
- Intranasal Vasopressin (AVP) 40 IU
- Lorazepam
Primary outcomes
- Healthy Volunteers-OT, Placebo: Mean Percent Signal Change in Right Caudate Nucleus in Men — Visit 1 (40-100 Minutes Post-Intervention)
The effect of the drug treatment will be assessed by determining differences in brain activation between OT and placebo groups in the right caudate nucleus region during reciprocated cooperation in Prisoner Dilemma game while undergoing an fMRI scan. - Healthy Volunteers-OT, Placebo: Mean Percent Signal Change in Right Caudate Nucleus in Women — Visit 1 (40-100 Minutes Post-Intervention)
The effect of the drug treatment will be assessed by determining differences in brain activation between OT and placebo groups in the right caudate nucleus region during reciprocated cooperation in Prisoner Dilemma game while undergoing an fMRI scan. - Healthy Volunteers-AVP, Placebo: Mean Percent Signal Change in Left Insula in Men — Visit 1 (40-100 Minutes Post-Intervention)
The effect of the drug treatment will be assessed by determining differences in brain activation between AVP and placebo groups in the left insula region during reciprocated cooperation in Prisoner Dilemma game while undergoing an fMRI scan. - Healthy Volunteers-AVP, Placebo: Mean Percent Signal Change in Left Insula in Women — Visit 1 (40-100 Minutes Post-Intervention)
The effect of the drug treatment will be assessed by determining differences in brain activation between AVP and placebo groups in the left insula during reciprocated cooperation in Prisoner Dilemma game while undergoing an fMRI scan. - Within Subject Group: Mean Percent Signal Change in Left Caudate Nucleus in Men and Women — Visit 1 (30-75 Minutes Post-Intervention), Visit 2 (Up to 2 Weeks)
The effect of the drug will be assessed by determining changes in brain activation between the visit where the participant received drug and the visit where the participant received PL in the right caudate during reciprocated cooperation in Prisoner Dilemma game while undergoing an fMRI scan.
Countries
United States