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Treatment of Bronchial Asthma With Borage and Echium Seed Oils
This study plans to look at whether borage and echium seed oils (natural oils from two plants) help decrease asthma symptoms and affect cells involved in inflammation. The investigators also want to look at how these plant oils decrease the generation of inflammatory cells in people with asthma.
Details
| Lead sponsor | Brigham and Women's Hospital |
|---|---|
| Phase | Phase 3 |
| Status | COMPLETED |
| Enrolment | 62 |
| Start date | 2013-02 |
| Completion | 2015-05 |
Conditions
- Asthma
Interventions
- Borage and Echium Seed Oils
- Corn oil pills
Primary outcomes
- Cellular Changes That Occur With Borage and Echium Seed Oil Supplementation — Assessed at 2, 8, 14, and 20 weeks
Primary outcome measures will be changes in the generation of LTC4 production by granulocytes. This was calculated by the difference between the amount produced at the start of each arm and at the end of each arm (i.e., two values were obtained in each arm and used to calculate the difference, and the differences were compared as a delta-delta). - Change in LTB4 Production — At 2, 8, 14, and 20 weeks
Primary outcome measures will be changes in the generation of LTB4 production by granulocytes. This was calculated by the difference between the amount produced at the start of each arm and at the end of each arm (i.e., two values were obtained in each arm and used to calculate the difference, and the differences were compared as a delta-delta). A negative number implies that the level of LTB4 produced by granulocytes at the end of the arm was less than the amount produced at the start of the arm, while a positive number means that more was generated at the end than at the beginning.
Countries
United States