NCT01541345 is a Phase 3 clinical trial of Autogenous bone graft in Missing Teeth, sponsored by University of Zurich.

Who is sponsoring NCT01541345?

NCT01541345 is sponsored by University of Zurich.

What drugs are being tested in NCT01541345?

Interventions in NCT01541345: Autogenous bone graft, InductOs, Augmentation surgery.

What condition does NCT01541345 study?

NCT01541345 studies Missing Teeth.

Is NCT01541345 still recruiting?

NCT01541345 is currently completed. Last updated 21 November 2021.

Last reviewed 2021-11-21 · How we verify

NCT01541345

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Phase III, Randomized, Controlled Clinical Trial of Lateral Ridge Augmentation Using Autogenous Bone Blocks or Xenogenic Bone Block Grafts Loaded With Recombinant Human Bone Morphogenic Protein 2

Completed Phase 3 Last updated 21 November 2021

What this trial tests

Phase 3 trial testing Autogenous bone graft in Missing Teeth in 24 participants. Completed in 4 June 2019.

Timeline

1 February 2011

Primary endpoint
25 April 2014

4 June 2019

Quick facts

Lead sponsor	University of Zurich
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	supportive care
Enrollment	24
Start date	1 February 2011
Primary completion	25 April 2014
Estimated completion	4 June 2019
Sites	2 locations across Austria, Switzerland

Drugs / interventions tested

Autogenous bone graft — full drug profile →
InductOs (DIBOTERMIN ALFA) — full drug profile →
Augmentation surgery

Conditions studied

Missing Teeth — all drugs for Missing Teeth →

Sponsor

University of Zurich

Who can join

Adults 20 to 75, any sex, with Missing Teeth. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Bone quality/quantity
Time frame: 4 month after augmentation surgery
Bone quantity at 4 months after augmentation surgery, measured manually by ridge measurements and volumetrically on the basis of optical impressions and radiological assessment (X-ray and cone beam CT). Bone quality at 4 months after augmentation surgery, measured by histological assessment (yields different proportion per patient).

Sponsor's own description

Since there are no clinical studies available comparing the gold standard (autogenous bone graft plus resorbable membrane) to the promising combination of xenogenic bone graft loaded with rhBMP-2 in combination with a collagen membrane for localized ridge augmentation, the present exploratory study has been designed. The aim of the present study is therefore to test whether or not the application of a xenogenic bone block loaded with rhBMP-2 will results in clinically, radiographically and histologically similar outcomes as the gold standard (autogenous bone block) for the regeneration of chronic ridge defects. The investigators expect that there is no difference in bone quantity and quality between the two methods and that the use of the test treatment will be more user and patient friendly according to the patient perception/acceptance since no second surgical site will be necessary as well as cause less complications.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of Autogenous bone graft

Trials testing the same drug.

NCT03302429 — Evaluation of Platelet Rich Fibrin / Biphasic Calcium Phosphate Effect Versus Autogenous Bone Graft on Reconstruction of · NA · completed

Other recruiting trials for Missing Teeth

Currently open trials in the same condition.

NCT06837688 — Enhancing Soft Tissues Around Inserted Implants by Two Different Methods · NA · recruiting
NCT06651502 — Efficacy of a Dental Implant System for Immediate Restoration · NA · active not recruiting
NCT05362591 — Anterior Resin Bonded Restorations for Adolescent · NA · active not recruiting
NCT04581304 — The Use of Bio-Oss Collagen for Sinus Augmentation Using the Transcrestal Approach. · NA · active not recruiting
NCT04741906 — Outcome of Dental Implant Therapy in Patients Treated With Antiresorptive Medication · recruiting

Other University of Zurich trials

Trials by the same sponsor.

NCT07485699 — Soy Processing and Food Allergy · NA · not yet recruiting
NCT07516912 — Evaluation of Free STI Testing Pilot Projects in Lucerne and Zurich, Switzerland · not yet recruiting
NCT07473115 — Individualized Analgesia in the Intensive Care Unit With a New Pain Assessment Bundle and Protocolized Analgesia Adjustm · not yet recruiting
NCT07524023 — Emotional-distress-based Integrated Care Programme in Patients With Stable COPD · NA · recruiting
NCT06481982 — Value of Advanced MRI Techniques in the Assessment of Endometriosis · withdrawn

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01541345 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Zurich
Last refreshed: 21 November 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01541345.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing