Metformin for the Treatment of Unexplained Oligozspermia and Azoospermia

NCT01529177 Phase 4 UNKNOWN

Insulin resistance (IR) in men may be the underlying pathogenesis for metabolic abnormalities and chronic hypospermatogenesis similar to women with polycystic ovarian disease (PCOD). Infertile men with unexplained infertility and IR may benefit from treatment with metformin.

Details

Lead sponsor	The Egyptian IVF-ET Center
Phase	Phase 4
Status	UNKNOWN
Enrolment	600
Start date	2012-02
Completion	2017-02

Conditions

• Infertility

Interventions

• Metformin / clomid / hCG
• Clomiphene citrate / hCG

Primary outcomes

• sperm count — 6 months
  semen analysis before the start of metformin and then every month for 6 months

Countries

Egypt