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NCT01521754: MORE
Product Surveillance Registry- Deep Brain Stimulation for Epilepsy
trial in Refractory Epilepsy in 191 participants. Completed in 19 June 2019.
19 June 2019
Quick facts
| Lead sponsor | MedtronicNeuro |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 191 |
| Start date | 6 March 2012 |
| Primary completion | 19 June 2019 |
| Estimated completion | 19 June 2019 |
| Sites | 27 locations across Italy, Finland, Netherlands, Russia, Belgium, Austria, Sweden, United Kingdom |
Conditions studied
- Refractory Epilepsy — all drugs for Refractory Epilepsy →
Sponsor
MedtronicNeuro — full company profile →
Who can join
18 and older, any sex, with Refractory Epilepsy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this observational registry is to evaluate the long-term effectiveness, safety and performance of market-released Medtronic Neuromodulation products for Deep Brain Stimulation (DBS) for the treatment of refractory epilepsy. In addition, healthcare resource use and patient reported outcomes, such as health related quality of life will be assessed.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry.
Peltola J, Colon AJ, Pimentel J, Coenen VA, et al · · 2023 · cited 60× · PMID 36927882 · DOI 10.1212/wnl.0000000000206887 -
Deep Brain Stimulation for the Management of Refractory Neurological Disorders: A Comprehensive Review.
Rissardo JP, Vora NM, Tariq I, Mujtaba A, et al · · 2023 · cited 17× · PMID 38004040 · DOI 10.3390/medicina59111991 -
Clinical Trials Examining Deep Brain Stimulation for the Treatment of Epilepsy: An Analysis of the Current State.
Gould J, Patel S, Chaurasia B. · · 2025 · PMID 41446446 · DOI 10.7759/cureus.97571 -
Is MORE better? Accumulating Evidence for ANT DBS in Epilepsy
· 2023
Verify or expand the search:
- PubMed search for NCT01521754
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Refractory Epilepsy
Currently open trials in the same condition.
- NCT06425029 — Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application · NA · recruiting
- NCT06524479 — Investigating the Functional Characteristics During Wakefulness and Sleep Based on SEEG · NA · recruiting
- NCT06241963 — High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Refractory Epilepsy · NA · recruiting
- NCT06396494 — An Automated Navigation System for Deep Brain Electrode Implantation · active not recruiting
- NCT05493722 — Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy · EARLY_PHASE1 · recruiting
Other MedtronicNeuro trials
Trials by the same sponsor.
- NCT05775510 — Study to Evaluate Neuromodulation Subject Experience With Contemporary Spinal Cord Stimulation (SCS) Modalities for Chro · terminated
- NCT05226286 — Evaluation of Implantable Tibial Neuromodulation Pivotal Study (TITAN 2) · NA · completed
- NCT05200923 — Pelvic Health Electrically Evoked Recording (PEER) 2 Study · NA · recruiting
- NCT05177354 — Medtronic Closed-Loop Spinal Cord Stimulation System · NA · completed
- NCT07106242 — Adaptive Deep Brain Stimulation (aDBS) Study (Early Adapter) Part II · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT01521754 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by MedtronicNeuro
- Last refreshed: 11 December 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01521754.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing