NCT01509976

Triclosan, Triclocarban, and the Microbiota

Completed NA Last updated 17 March 2021

What this trial tests

NA trial testing triclosan/triclocarban-containing personal care products in Triclosan Effects on Microbial Flora in 20 participants. Completed in 31 December 2017.

Timeline

1 July 2011

Primary endpoint
1 October 2015

31 December 2017

Quick facts

Lead sponsor	Stanford University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	other
Enrollment	20
Start date	1 July 2011
Primary completion	1 October 2015
Estimated completion	31 December 2017
Sites	1 location across United States

Drugs / interventions tested

• triclosan/triclocarban-containing personal care products

Conditions studied

• Triclosan Effects on Microbial Flora — all drugs for Triclosan Effects on Microbial Flora →

Sponsor

Stanford University

Who can join

18 and older, any sex, with Triclosan Effects on Microbial Flora. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Triclosan (5-chloro-2 (22,4-dichlorophenoxy)phenol) is a broad-spectrum antibacterial and antifungal agent that is found in thousands of common household products, including deodorants, toothpaste, "antibacterial" soaps, cleaning products, kitchen utensils, bedding, socks, trash bags. The benefits of triclosan have not been proven except in reducing plaque and gingivitis when used in toothpaste. In this study, the investigators intend to look at whether exposure to triclosan changes the colonizing flora of the skin, gut and mouth as well as changes in certain blood hormone levels, including adipocytokines, androgens, and inflammatory markers. Changes in the gut microbiota have been associated with a variety of disease states such as inflammatory bowel disease, colorectal cancer. Additionally, reductions in the microbiome diversity have been associated with obesity.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.
   Zhang J, Walker ME, Sanidad KZ, Zhang H, et al · · 2022 · cited 74× · PMID 35013263 · DOI 10.1038/s41467-021-27762-y
2. Crossover Control Study of the Effect of Personal Care Products Containing Triclosan on the Microbiome.
   Poole AC, Pischel L, Ley C, Suh G, et al · · 2016 · cited 47× · PMID 27303746 · DOI 10.1128/msphere.00056-15
3. Metabolic fate of environmental chemical triclocarban in colon tissues: roles of gut microbiota involved.
   Wang G, Zhang H, Zhang J, Sanidad KZ, et al · · 2021 · cited 15× · PMID 34004538 · DOI 10.1016/j.scitotenv.2021.147677
4. Microbiota-mediated reactivation of triclosan oxidative metabolites in colon tissues.
   Zhang H, Sanidad KZ, Zhang J, Wang G, et al · · 2023 · cited 8× · PMID 36463744 · DOI 10.1016/j.jhazmat.2022.130509