Effects of Nebivolol Versus Metoprolol on Blood Flow Responses to Exercise and Angiotensin II in Hypertensive Patients

NCT01502787 Phase 4 COMPLETED Results posted

The purpose of this study is to determine if Nebivolol a) attenuates the angiotensin II (Ang II)-induced increase in oxidative stress, thereby attenuating Ang II-induced vasoconstriction; and b) attenuates sympathetic mediated vasoconstriction during exercise, thereby reducing functional skeletal muscle ischemia in hypertensive patients.

Details

Lead sponsor	University of Texas Southwestern Medical Center
Phase	Phase 4
Status	COMPLETED
Enrolment	46
Start date	2009-04
Completion	2013-06

Conditions

• Hypertension

Interventions

• Metoprolol succinate
• Nebivolol
• Forearm blood flow
• Microneurography
• Rhythmic handgrip exercise
• Lower body negative pressure
• Angiotensin II

Primary outcomes

• Forearm Blood Flow — 12 weeks after each specified medication

Countries

United States