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The Effect of Small-dose Ketamine on Depression of Respiratory and Cardiac Functions Caused by Propofol in Pediatric Cardiac Catheterization
Normal cardiac and respiratory functions should be maintained during pediatric cardiac catheterization. Propofol has become a popular choice for sedation in children, however, it depresses cardiac and respiratory functions. Some investigators reported that ketamine attenuates its depressant effect, but it remains unclear whether ketamine reduces cardiac and respiratory depression caused by propofol in pediatric cardiac catheterization.
Details
| Lead sponsor | Ibaraki Children's Hospital |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 150 |
| Start date | 2012-01 |
| Completion | 2013-05 |
Conditions
- Congenital Heart Disease
- Sedated for Cardiac Catheterization
Interventions
- control
- Ket10
- Ket20
Primary outcomes
- difference of end tidal partial pressure of carbon dioxide between the groups — 30 and 60 min after anesthetic induction
- difference of partial pressure of arterial carbon dioxide between the groups — 60 min after anesthetic induction on average
- heart rate change from baseline value — 30 and 60 min after anesthetic induction
- non-invasive blood pressure change from baseline value — 30 and 60 min after anesthetic induction
Countries
Japan